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Human fibroblasts in vitro senesce with a donor-specific telomere length

Lookup NU author(s): Professor Thomas von Zglinicki

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Abstract

In human fibroblasts, replicative senescence, telomere length and donor age are closely interrelated. We analyzed these relationships for fibroblast strains from 14 healthy human donors in the age range of 28-90 years. In vitro replicative capacity was correlated more closely with donor age than with telomere length ex vivo, especially for healthy donors. Telomere length at senescence was as variable as at cell explantation and increased with donor age. The data suggest a donor-specific, age-dependent regulation of the telomere length threshold that triggers senescence in human fibroblasts. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

Publication metadata

Author(s): von Zglinicki T; Serra V

Publication type: Article

Publication status: Published

Journal: FEBS Letters

Year: 2002

Volume: 516

Issue: 1-3

Pages: 71-74

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/S0014-5793(02)02504-8

DOI: 10.1016/S0014-5793(02)02504-8

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