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Lookup NU author(s): Dr Richard Quinton
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Three new studies into the function of human anosmin-1 and related proteins in C. elegans and rodents show that these influence axon branching and axon targeting. The rodent anosmin appears to work at two stages of development, initially promoting axon outgrowth from the olfactory bulb and then stimulating branching from axons into the olfactory cortex. CeKal-1 further influences morphogenesis, and, as the human and nematode anosmins are functionally conserved, these studies provide insights into the pathogenesis of Kallmann syndrome (KS).
Author(s): MacColl G, Bouloux P, Quinton R
Publication type: Review
Publication status: Published
Journal: Neuron
Year: 2002
Volume: 34
Issue: 5
Pages: 675-678
ISSN (print): 0896-6273
ISSN (electronic): 1097-4199
URL: http://dx.doi.org/10.1016/S0896-6273(02)00720-1
DOI: 10.1016/S0896-6273(02)00720-1
