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Molecular mediators of Porphyromonas gingivalis-induced T-cell apoptosis

Lookup NU author(s): Emeritus Professor Roy Russell, Dr John TaylorORCiD

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Abstract

Porphyromonas gingivalis produces virulence factors which can modify the molecular and cellular components of the host immune response. In the present work we investigated the role of specific virulence factors from P. gingivalis in the induction of apoptosis in Jurkat T cells. P. gingivalis culture supernatants mimicked the effect of butyric acid on T-cell apoptosis and this effect was associated with an increase in histone H4 acetylation. A role for proteases was excluded in experiments which demonstrated that neither protease inhibitors nor use of P. gingivalis mutants defective in protease synthesis had any effect on the stimulation of T-cell apoptosis in this system.

Publication metadata

Author(s): Russell RRB; Taylor JJ; Harris JI; Curtis MA; Aduse-Opoku J

Publication type: Article

Publication status: Published

Journal: Oral Microbiology and Immunology

Year: 2002

Volume: 17

Issue: 4

Pages: 224-230

ISSN (print): 0902-0055

ISSN (electronic): 1399-302X

Publisher: Wiley-Blackwell Publishing, Inc.

URL: http://dx.doi.org/10.1034/j.1399-302X.2002.170404.x

DOI: 10.1034/j.1399-302X.2002.170404.x

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