Lookup NU author(s): Emeritus Professor Roy Russell,
Dr John Taylor
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Porphyromonas gingivalis produces virulence factors which can modify the molecular and cellular components of the host immune response. In the present work we investigated the role of specific virulence factors from P. gingivalis in the induction of apoptosis in Jurkat T cells. P. gingivalis culture supernatants mimicked the effect of butyric acid on T-cell apoptosis and this effect was associated with an increase in histone H4 acetylation. A role for proteases was excluded in experiments which demonstrated that neither protease inhibitors nor use of P. gingivalis mutants defective in protease synthesis had any effect on the stimulation of T-cell apoptosis in this system.
Author(s): Russell RRB; Taylor JJ; Harris JI; Curtis MA; Aduse-Opoku J
Publication type: Article
Publication status: Published
Journal: Oral Microbiology and Immunology
ISSN (print): 0902-0055
ISSN (electronic): 1399-302X
Publisher: Wiley-Blackwell Publishing, Inc.
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