Lookup NU author(s): Emeritus Professor Elaine Perry,
Professor David Burn,
Emeritus Professor Robert Perry
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The hypothesis that blockade of muscarinic receptors is associated with increased Alzheimer-type pathology was investigated in Parkinson's disease. Amyloid plaque densities were more than 2.5-fold higher in cases treated with antimuscarinic medication in the long term compared with untreated or short-term treated cases (p = 0.005 and 0.00005, respectively). Neurofibrillary tangle densities were also highest in chronic compared with untreated or acute-treated groups (p = 0.02 and 0.05, respectively). The findings, if replicated, have potential implications for the use of anticholinergic medication in elderly Parkinson's disease patients.
Author(s): Perry RH; Perry EK; Burn DJ; Kilford L; Lees AJ
Publication type: Article
Publication status: Published
Journal: Annals of Neurology
ISSN (print): 0364-5134
ISSN (electronic): 1531-8249
Publisher: John Wiley & Sons, Inc.
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