Browse by author
Lookup NU author(s): David Rawlings, Emeritus Professor Roger Francis, Dr Nicholas Thompson
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
Background: Osteoporosis is a common complication of Crohn's disease. Aim: To study the effect on the bone mineral density of a bisphosphonate (pamidronate) given intravenously, in combination with oral calcium and vitamin D supplements, compared with oral calcium and vitamin D supplements alone. Methods: Seventy-four patients with Crohn's disease and low bone mineral density at the lumbar spine and/or hip were randomized to receive either a daily dose of 500 mg of calcium with 400 IU of vitamin D alone or in combination with four three-monthly infusions of 30 mg of intravenous pamidronate over the course of 12 months. The main outcome measure was the change in bone mineral density at the lumbar spine and hip, measured by dual X-ray absorptiometry, at baseline and 12 months. Results: Both groups gained bone mineral density at the lumbar spine and hip after 12 months. There were significant (P < 0.05) changes in the pamidronate group, with gains of + 2.6%[95% confidence interval (CI), 1.4-3.0] at the spine and + 1.6% (95% CI, 0.6-2.5) at the hip, compared with gains of + 1.6% (95% CI, - 0.1-3.2) and + 0.9% (95% CI, - 0.4-2.1) at the spine and hip, respectively, in the group taking vitamin D and calcium supplements alone. Conclusions: In patients with Crohn's disease and low bone mineral density, intravenous pamidronate significantly increases the bone mineral density at the lumbar spine and hip.
Author(s): Bartram SA, Peaston RT, Rawlings DJ, Francis RM, Thompson NP
Publication type: Article
Publication status: Published
Journal: Alimentary Pharmacology and Therapeutics
Year: 2003
Volume: 18
Issue: 11-12
Pages: 1121-1127
ISSN (print): 0269-2813
ISSN (electronic): 1365-2036
Publisher: Wiley-Blackwell Publishing
URL: http://dx.doi.org/10.1046/j.0269-2813.2003.01794.x
DOI: 10.1046/j.0269-2813.2003.01794.x
Altmetrics provided by Altmetric
