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The waiting game: bridging to paediatric heart transplantation

Lookup NU author(s): Dr Jane Cassidy, Andrew Davison

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Abstract

Background Although mechanical circulatory support might not increase the number of adults surviving to transplantation, because of the shortage of donor organs, the situation might be different for children. Our aim was to assess the effect of mechanical assist devices to bridge children with end-stage cardiomyopathy to heart transplantation. Methods A 5-year retrospective review was undertaken with data from the UK paediatric transplant programme and from bridging to transplant done at two paediatric transplant centres in the UK. Findings Between Jan 1, 1998 and Dec 31, 2002, 22 children with end-stage cardiomyopathy, median age 5.7 years (range 1.2-17), were supported by a mechanical assist device as a bridge to first heart transplantation, with a 77% survival rate to hospital discharge. Nine were supported by a paracorporeal ventricular assist device, six received transplantation, five survived to discharge (55%), with one late death. 13 were supported by extra-corporeal membrane oxygenation, and 12 were transplanted and survived to discharge (92%) with one late death. With urgent listing, the median waiting time for a heart was 7.5 days (range 1.5-22 days). The correlation between the proportion of patients bridged to transplantation and the proportion of patients dying while on the transplant waiting list was r=-0.93, p=0.02. Interpretation Our findings lend support to the hypothesis that a national mechanical assist programme to bridge children to transplantation can minimise the number dying while on the heart transplant waiting list. In the context of urgent listing and a short waiting time, extra-corporeal membrane oxygenation seems to provide the safest form of support.

Publication metadata

Author(s): Goldman AP, Cassidy J, de Leval M, Haynes S, Brown K, Whitmore P, Cohen G, Tsang V, Elliott M, Davison A, Hamilton L, Bolton D, Wray J, Hasan A, Radley-Smith R, Macrae D, Smith J

Publication type: Article

Publication status: Published

Journal: The Lancet

Year: 2003

Volume: 362

Issue: 9400

Pages: 1967-1970

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group

URL: http://dx.doi.org/10.1016/S0140-6736(03)15015-5

DOI: 10.1016/S0140-6736(03)15015-5

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