Toggle Main Menu Toggle Search

Open Access padlockePrints

Laminar distribution of neurofilament inclusions and swollen achromatic neurons in neurofilament inclusion disease (NID)

Lookup NU author(s): Dr Evelyn Jaros, Emeritus Professor Robert Perry

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

The laminar distribution of the neurofilament inclusions (NI) and swollen achromatic neurons (SN) was studied in gyri of the temporal cortex in four patients with neurofilament inclusion disease (NID). In 84% of gyri analysed, the density of the NI was maximal in the lower cortical laminae. The distribution of the SN was more variable than the NI. Density was maximal in the lower cortex in 46% of gyri, in the upper cortical laminae in 8% of gyri, and a bimodal distribution in 15% of gyri. In the remaining gyri, there was a more even distribution of SN with cortical depth. In 31% of gyri, the vertical density of the NI was positively correlated with that of the SN. The data suggest that cortical degeneration in the temporal lobe of NID initially affects neurons in the lower laminae. Subsequently, the pathology may spread to affect much of the cortical profile, the SN preceding the appearance of the NI.


Publication metadata

Author(s): Cairns NJ, Jaros E, Perry RH, Amstrong RA

Publication type: Article

Publication status: Published

Journal: Neuroscience Research Communications

Year: 2004

Volume: 34

Issue: 2

Pages: 104-111

ISSN (print): 0893-6609

ISSN (electronic):

Publisher: John Wiley & Sons Ltd.

URL: http://dx.doi.org/10.1002/nrc.20004

DOI: 10.1002/nrc.20004


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share