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Lookup NU author(s): Dr Evelyn Jaros, Emeritus Professor Robert Perry
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The laminar distribution of the neurofilament inclusions (NI) and swollen achromatic neurons (SN) was studied in gyri of the temporal cortex in four patients with neurofilament inclusion disease (NID). In 84% of gyri analysed, the density of the NI was maximal in the lower cortical laminae. The distribution of the SN was more variable than the NI. Density was maximal in the lower cortex in 46% of gyri, in the upper cortical laminae in 8% of gyri, and a bimodal distribution in 15% of gyri. In the remaining gyri, there was a more even distribution of SN with cortical depth. In 31% of gyri, the vertical density of the NI was positively correlated with that of the SN. The data suggest that cortical degeneration in the temporal lobe of NID initially affects neurons in the lower laminae. Subsequently, the pathology may spread to affect much of the cortical profile, the SN preceding the appearance of the NI.
Author(s): Cairns NJ, Jaros E, Perry RH, Amstrong RA
Publication type: Article
Publication status: Published
Journal: Neuroscience Research Communications
Year: 2004
Volume: 34
Issue: 2
Pages: 104-111
ISSN (print): 0893-6609
ISSN (electronic):
Publisher: John Wiley & Sons Ltd.
URL: http://dx.doi.org/10.1002/nrc.20004
DOI: 10.1002/nrc.20004
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