Lookup NU author(s): Emeritus Professor Elaine Perry,
Dr Iryna Ziabreva,
Emeritus Professor Robert Perry,
Dr Dag Aarsland,
Dr Clive Ballard
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Choline acetyltransferase in temporal cortex was evaluated as a marker of cholinergic function in autopsied dementia cases ( 9 vascular dementia [VaD] cases, 12 "mixed" VaD and Alzheimer disease [AD] cases, 10 AD cases, 12 control subjects). Patients with AD (t = 2.5, p = 0.02) and "mixed" VaD and AD (t = 3.8, p = 0.001) had greater cholinergic deficits than age-matched control subjects and patients with "pure" VaD. The absence of cholinergic deficits in "pure" VaD may be relevant to the pharmacologic treatment of these patients.
Author(s): Perry E, Ziabreva I, Perry R, Aarsland D, Ballard C
Publication type: Article
Publication status: Published
ISSN (print): 0028-3878
ISSN (electronic): 1526-632X
Publisher: AAN Enterprises, Inc