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BDNF genetic variants are associated with onset age of familial Parkinson disease: GenePD study

Lookup NU author(s): Professor David Burn, Professor Patrick Chinnery

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Abstract

Brain-derived neurotrophic factor ( BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

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Author(s): Karamohamed S, Latourelle JC, Racette BA, Perlmutter JS, Wooten GF, Lew M, Klein C, Shill H, Golbe LI, Mark MH, Guttman M, Nicholson G, Wilk JB, Saint-Hilaire M, DeStefano L, Prakash R, Tobin S, Williamson J, Suchowersky O, Labell N, Growdon BNJ, Singer C, Watts R, Goldwurm S, Pezzoli G, Baker KB, Giroux ML, Pramstaller PP, Burn DJ, Chinnery P, Sherman S, Vieregge P, Litvan I, Gusella JF, Myers RH, Parsian A

Publication type: Article

Publication status: Published

Journal: Neurology

Year: 2005

Volume: 65

Issue: 11

Pages: 1823-1825

ISSN (print): 0028-3878

ISSN (electronic): 1526-632X

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1212/01.wnl.0000187075.81589.fd

DOI: 10.1212/01.wnl.0000187075.81589.fd

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