Lookup NU author(s): Professor Peter Blain CBE
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
There is no specific antidote for the treatment of casualties exposed to chlorine, phosgene, or mustards; therefore, management is largely supportive. Corticosteroid treatment has been given to casualties accidentally exposed to chlorine. Clinical data on efficacy are inconclusive as the numbers given steroids have been small and the indications for administration unclear. There have been no clinical controlled studies. There is a stronger evidence base from animal studies, particularly from porcine and rodent models. Lung injury induced by phosgene and mustard appears to be mediated by glutathione depletion, lipid peroxidation, free radical generation, and subsequent cellular toxicity. There is limited evidence to suggest that repletion of glutathione reduces and/or prevents lung damage by these agents. This may provide an opportunity for therapeutic intervention.
Author(s): Russell D, Blaine PG, Rice P
Publication type: Review
Publication status: Published
Journal: Emergency Medicine Journal
ISSN (print): 1472-0205
ISSN (electronic): 1472-0213