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Lookup NU author(s): Marian Case,
Emeritus Professor Andy Hall,
Dr Linda Hogarth,
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Simple amino acid prodrugs of cysteamine and cystamine were synthesized to overcome the problems of palatability and gastrointestinal irritation, while gamma-glutamyl prodrugs were synthesized to target the parent drug to gamma-glutamyl transpepticlase (GGT). Preliminary cystine-depleting evaluation in vitro suggests further investigation is warranted. Low toxicity of the prodrugs was observed.
Author(s): Anderson RJ, Cairns D, Cardwell WA, Case MC, Groundwater PW, Hall AG, Hogarth LA, Jones AL, Meth-Cohn O, Suryadevara P, Tindall A, Thoene JG
Publication type: Article
Publication status: Published
Journal: Letters in Drug Design & Discovery
ISSN (print): 1570-1808
ISSN (electronic): 1875-628X
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