Toggle Main Menu Toggle Search

Open Access padlockePrints

Design, synthesis and initial in vitro evaluation of novel prodrugs for the treatment of cystinosis

Lookup NU author(s): Marian Case, Emeritus Professor Andy Hall, Dr Linda Hogarth, Amanda Jones

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Simple amino acid prodrugs of cysteamine and cystamine were synthesized to overcome the problems of palatability and gastrointestinal irritation, while gamma-glutamyl prodrugs were synthesized to target the parent drug to gamma-glutamyl transpepticlase (GGT). Preliminary cystine-depleting evaluation in vitro suggests further investigation is warranted. Low toxicity of the prodrugs was observed.


Publication metadata

Author(s): Anderson RJ, Cairns D, Cardwell WA, Case MC, Groundwater PW, Hall AG, Hogarth LA, Jones AL, Meth-Cohn O, Suryadevara P, Tindall A, Thoene JG

Publication type: Article

Publication status: Published

Journal: Letters in Drug Design & Discovery

Year: 2006

Volume: 3

Issue: 5

Pages: 336-345

ISSN (print): 1570-1808

ISSN (electronic): 1875-628X

URL: http://dx.doi.org/10.2174/157018006777574258

DOI: 10.2174/157018006777574258


Altmetrics

Altmetrics provided by Altmetric


Actions

Find at Newcastle University icon    Link to this publication


Share