Lookup NU author(s): Dr Malcolm Coulthard
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Growth failure is a recognised feature of Gitelman syndrome, although it is not as frequent as in Bartter syndrome. Indometacin is reported to improve growth in Bartter syndrome, hut not in Gitelman syndrome, where magnesium supplements are recommended. This paper presents 3 sisters with Gitelman syndrome who could not tolerate magnesium supplements, and whose hypotension and polyuria were eliminated by taking 2 mg/kg/day indometacin, bur who grew poorly. However, increasing the indometacin dose to 4 mg/kg/day improved their growth significantly, without changing their symptoms or biochemistry. Gastrointestinal haemorrhage necessitated the use of misoprostol.
Author(s): Liaw LCT, Banerjee K, Coulthard MG
Publication type: Article
Publication status: Published
Journal: Archives of Disease in Childhood
Print publication date: 01/12/1999
ISSN (print): 0003-9888
ISSN (electronic): 1468-2044
Publisher: BMJ Group
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