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Lookup NU author(s): Emeritus Professor John Davison, Professor Peter Baylis, Dr Sally Thornton
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It is not known whether human labour is associated with increased fetal oxytocin production or transfer of oxytocin across the placenta. Previous reports are contradictory, due in part, to the influence of maternal analgesia on fetal production. We determined plasma oxytocin concentration in the umbilical artery and vein of women after Vaginal delivery and after caesarean section with general anaesthesia before or after the onset of labour. The results demonstrate that fetal production of oxytocin is not influenced by general anaesthesia, thus enabling comparison of labour and nonlabour samples at caesarean section. Labour was not associated with an increase in fetal oxytocin production. Oxytocin was also measured in the umbilical artery and vein during maternal oxytocin infusion to assess placental transfer. The results do not support transfer of oxytocin across the placenta in women.
Author(s): Thornton S; Baylis PH; Davison JM; Patient C; Charlton L
Publication type: Article
Publication status: Published
Journal: British Journal of Obstetrics & Gynaecology
Year: 1999
Volume: 106
Issue: 12
Pages: 1311-1313
Print publication date: 01/12/1999
ISSN (print): 1470-0328
ISSN (electronic):
Publisher: Wiley-Blackwell Publishing Ltd.
URL: http://dx.doi.org/10.1111/j.1471-0528.1999.tb08188.x
DOI: 10.1111/j.1471-0528.1999.tb08188.x
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