Lookup NU author(s): Professor Ian McKeith,
Dr Christopher Morris
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.
Author(s): McKeith IG; Morris CM; Xu WM; Liu LZ; Emson P; Harrington CR; Perry RH; Charles IG
Publication type: Article
Publication status: Published
ISSN (print): 0959-4965
ISSN (electronic): 1473-558X
Publisher: Lippincott Williams & Wilkins
Altmetrics provided by Altmetric