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The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

Lookup NU author(s): Professor Ian McKeith, Dr Christopher Morris

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Abstract

We report the analysis of the allele distribution of a (CCTTT)n pentanucleotide repeat within the promoter region of the NOS2A gene in DNA samples from patients with autopsy confirmed Alzheimer's disease (AD) and dementia with Lewy bodies (DLB) type. A significant difference was observed in the allelic distribution between the control group and the DLB group (chi(2) = 15.175, df = 5; p < 0.01), with an increased occurrence of the eight and nine repeat alleles, and a marked under representation of the 11 repeat allele. Genotype frequencies in the DLB group also differed significantly from controls (p<0.012). These results suggest that variations in the NOS2A gene may predispose to the development of DLB. NeuroReport 11:297-299 (C) 2000 Lippincott Williams & Wilkins.


Publication metadata

Author(s): McKeith IG; Morris CM; Xu WM; Liu LZ; Emson P; Harrington CR; Perry RH; Charles IG

Publication type: Article

Publication status: Published

Journal: Neuroreport

Year: 2000

Volume: 11

Issue: 2

Pages: 297-299

ISSN (print): 0959-4965

ISSN (electronic): 1473-558X

Publisher: Lippincott Williams & Wilkins

URL: http://dx.doi.org/10.1097/00001756-200002070-00015

DOI: 10.1097/00001756-200002070-00015


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