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Melanocortin-1-receptor gene and sun sensitivity in individuals without red hair

Lookup NU author(s): Dr Eugene Healy, Dr Amanda Ray, Professor John Matthews, Professor Mark Birch-Machin, Professor Jonathan Rees

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Abstract

Susceptibility to sunburn, photoageing, and skin cancer is inversely related to an individual's ability to tan after sun exposure. We examined variants in the melanocortin-1-receptor (MC1R) gene in individuals from Ireland and the UK. We found evidence of an association between the degree of tanning after repeated sun exposure, and the number of variant alleles present. Heterozygotes were intermediate between wild-type individuals and those with two variant alleles. We suggest that MC1R gene status therefore determines sun sensitivity in people without red hair.


Publication metadata

Author(s): Healy E; Matthews JNS; Ray A; Birch-Machin MA; Rees JL; Flannagan N; Todd C; Jackson IJ

Publication type: Article

Publication status: Published

Journal: Lancet

Year: 2000

Volume: 355

Issue: 9209

Pages: 1072-1073

ISSN (print): 0140-6736

ISSN (electronic): 1474-547X

Publisher: The Lancet Publishing Group

URL: http://dx.doi.org/10.1016/S0140-6736(00)02042-0

DOI: 10.1016/S0140-6736(00)02042-0


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