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Dinucleotide repeat polymorphism in the interleukin-10 gene promoter (IL-10.G) and genetic susceptibility to early-onset periodontal disease

Lookup NU author(s): Judith Parkhill, Professor Peter Heasman, Dr John Taylor

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Abstract

Emerging evidence suggests that certain genetic polymorphisms are associated with various sub-groups of early-onset periodontal diseases (EOP). We determined the genotype with respect to a (CA), dinucleotide repeat polymorphism in the promoter region of the interleukin-10 gene (IL-10.G) in 72 patients with EOP and in 73 healthy individuals in order to test for possible disease associations. Some differences between the frequency of individual IL. 10.G alleles in the patients groups as compared to the healthy controls were detected. For example the frequency of the IL-10.G9 allele in a clinical sub-group of the EOP patients with localised disease (L-EOP, n = 21) was 64.3% as compared to 41.8% in the controls. However, statistical analysis (Monte Carlo simulation) revealed that the differences in IL-10.G allele distribution between the healthy controls and both the EOP group and the L-EOP group were not statistically significant. We conclude that this study provides no evidence for a role of IL-10.G alleles in genetic susceptibility to EOP.


Publication metadata

Author(s): Heasman PA; Parkhill JM; Taylor JJ; Hennig BJW; Chapple ILC

Publication type: Article

Publication status: Published

Journal: Genes and Immunity

Year: 2000

Volume: 1

Issue: 6

Pages: 402-404

ISSN (print): 1476-5470

ISSN (electronic): 1466-4879

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.gene.6363687

DOI: 10.1038/sj.gene.6363687


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