Lookup NU author(s): Dr Matthew Walker,
Professor Ian McKeith,
Professor John O'Brien
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Background The identification of fluctuating confusion is central to improving the differential diagnosis of the common dementias. Aims To determine the value of two rating scales to measure fluctuating confusion. Method The agreement between the clinician-rated scale and the scale completed by a non-clinician was determined. Correlations between the two scales were calculated; variability in attention was calculated on a computerised cognitive assessment and variability in delta rhythm on an electroencephalogram (EEG). Results The Clinician Assessment of Fluctuation and the computerised cognitive assessment were completed for 155 patients (61 Alzheimer's disease, 37 dementia with Lewy bodies, 22 vascular dementia, 35 elderly controls). A subgroup (n=40) received a further evaluation using the One Day Fluctuation Assessment Scale and an EEG. The two scales correlated significantly with each other, and with the neuropsychological and electrophysiological measures of fluctuation. Conclusions Both scales are useful instruments for the clinical assessment of fluctuation in dementia. Declaration of interest None; source of funding: Medical Research Council.
Author(s): McKeith IG; O'Brien JT; Walker MP; Ayre GA; Cummings JL; Wesnes K; Ballard CG
Publication type: Article
Publication status: Published
Journal: British Journal of Psychiatry
ISSN (print): 0007-1250
ISSN (electronic): 1472-1465
Publisher: Royal College of Psychiatrists
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