Lookup NU author(s): Dr Christopher Morris
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A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha -synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha -synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.
Author(s): Khan N, Graham E, Dixon P, Morris C, Mander A, Clayton D, Vaughan J, Quinn N, Lees A, Daniel S, Wood N, de Silva R
Publication type: Article
Publication status: Published
Journal: Annals of Neurology
ISSN (print): 0364-5134
ISSN (electronic): 1531-8249
Publisher: John Wiley & Sons, Inc.
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