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Role of polymorphisms in the interleukin-10 gene in determining disease susceptibility and phenotype in inflamatory bowel disease

Lookup NU author(s): Dr Alison Sutherland, Professor Chris Day, Dr Mark Welfare, Professor Ann Daly, Dr John Mansfield, Dr Mark Hudson

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Abstract

Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation. The role of functional polymorphisms at positions -627 and -1117 in the IL-10 gene as candidate susceptibility loci in inflammatory bowel disease and their importance in determining disease extent were evaluated in 159 patients with ulcerative colitis (83 left-sided; 76 extensive), 90 patients with Crohn's disease (22 small bowel; 29 large bowel; 39 both), and 227 controls. Genotyping was performed either by PCR RFLP assays (-627 site) or SSCP analysis (-1117 site). An excess of -627A allele was observed in patients with left-sided colitis (52%) compared with controls (33%; P = 0.004) suggesting that IL-10 may influence the extent of the disease. These results were not replicated in a newly recruited group (N = 100) of patients with UC. We conclude that polymorphisms at -627 and -1117 sites in the IL-10 gene do not contribute to the susceptibility to IBD or determining the extent of the disease in our population.


Publication metadata

Author(s): Aithal GP, Craggs A, Day CP, Welfare M, Daly AK, Mansfield JC, Hudson M

Publication type: Article

Publication status: Published

Journal: Digestive Diseases and Sciences

Year: 2001

Volume: 46

Issue: 7

Pages: 1520-1525

ISSN (print): 0163-2116

ISSN (electronic): 1573-2568

Publisher: Springer New York LLC

URL: http://dx.doi.org/10.1023/A:1010604307776

DOI: 10.1023/A:1010604307776


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