Lookup NU author(s): Dr Alison Sutherland,
Professor Chris Day,
Dr Mark Welfare,
Professor Ann Daly,
Dr John Mansfield,
Dr Mark Hudson
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Interleukin-10 (IL-10) has a key role in regulating mucosal inflammation. The role of functional polymorphisms at positions -627 and -1117 in the IL-10 gene as candidate susceptibility loci in inflammatory bowel disease and their importance in determining disease extent were evaluated in 159 patients with ulcerative colitis (83 left-sided; 76 extensive), 90 patients with Crohn's disease (22 small bowel; 29 large bowel; 39 both), and 227 controls. Genotyping was performed either by PCR RFLP assays (-627 site) or SSCP analysis (-1117 site). An excess of -627A allele was observed in patients with left-sided colitis (52%) compared with controls (33%; P = 0.004) suggesting that IL-10 may influence the extent of the disease. These results were not replicated in a newly recruited group (N = 100) of patients with UC. We conclude that polymorphisms at -627 and -1117 sites in the IL-10 gene do not contribute to the susceptibility to IBD or determining the extent of the disease in our population.
Author(s): Aithal GP, Craggs A, Day CP, Welfare M, Daly AK, Mansfield JC, Hudson M
Publication type: Article
Publication status: Published
Journal: Digestive Diseases and Sciences
ISSN (print): 0163-2116
ISSN (electronic): 1573-2568
Publisher: Springer New York LLC
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