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Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls

Lookup NU author(s): Professor Patrick Chinnery, Dr Catherine Mowbray, Dr Sheila Patel, Dr Joanna Elson, Anne Hattersley, Professor Mark Walker

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Abstract

Mitochondria play a central role in the secretion of insulin by pancreatic beta-cells, and pathogenic mutations of mitochondrial DNA ( mtDNA) can cause diabetes. The aetiology of type 2 diabetes has a strong genetic component, raising the possibility that genetic variants of mtDNA alter the risk of developing the disorder. Recent studies have produced conflicting results. By studying 897 UK cases of type 2 diabetes and 1010 population- matched controls, it is shown that European mtDNA haplogroups are unlikely to play a major role in the risk of developing the disorder.

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Author(s): Chinnery PF, Mowbray C, Patel SK, Elson JL, Sampson M, Hitman GA, McCarthy MI, Hattersley AT, Walker M

Publication type: Article

Publication status: Published

Journal: Journal of Medical Genetics

Year: 2007

Volume: 44

Issue: 6

ISSN (print): 0022-2593

ISSN (electronic): 1468-6244

Publisher: BMJ Group

URL: http://dx.doi.org/10.1136/jmg.2007.048876

DOI: 10.1136/jmg.2007.048876

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