Publications by Professor David Brooks - ePrints

Browsing publications by Professor David Brooks.

Newcastle Authors	Title	Year
Professor David Brooks	Capillary dysfunction in healthy elderly APOE ε4 carriers with raised brain Aβ deposition	2024
Professor David Brooks	Performance on complex memory tests is associated with β-amyloid in individuals at risk of developing Alzheimer's disease	2024
Professor David Brooks Professor Nicola Pavese	Progression of brain cholinergic dysfunction in patients with isolated REM sleep behaviour disorder	2024
Professor David Brooks	Capillary dysfunction correlates with cortical amyloid load in early Alzheimer's disease	2023
Professor David Brooks	Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease	2023
Professor David Brooks	Neuroinflammation is independently associated with brain network dysfunction in Alzheimer’s disease	2023
Professor David Brooks	Selecting the Best Animal Model of Parkinson’s Disease for your Research Purpose: Insight from In Vivo PET Imaging Studies	2023
Professor Nicola Pavese Professor David Brooks	Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [¹¹C]UCB-J and [¹⁸F]FDG PET Study	2023
Professor Nicola Pavese Professor David Brooks	Synaptic Density and Glucose Consumption in Patients with Lewy Body Diseases: An [¹¹C]UCB-J and [¹⁸F]FDG PET Study	2023
Dr Emma Lethbridge Professor David Brooks	The noradrenergic subtype of Parkinson's disease: from animal models to clinical practice	2023
Professor David Brooks	Treadmill exercise modulates nigral and hippocampal cannabinoid receptor type 1 in the 6-OHDA model of Parkinson’s disease	2023
Professor David Brooks	[¹⁸F]FEOBV positron emission tomography may not be a suitable method to measure parasympathetic denervation in patients with Parkinson's disease	2022
Professor David Brooks	A genetically modified minipig model for Alzheimer’s disease with SORL1 haploinsufficiency	2022
Professor David Brooks	Asymmetric amyloid deposition in preclinical Alzheimer’s disease: A PET study	2022
Professor David Brooks	Capillary function progressively deteriorates in prodromal Alzheimer’s disease: A longitudinal MRI perfusion study	2022
Dr Hilmar Sigurdsson Professor Alison Yarnall Dr Brook Galna Dr Susan Lord Dr Lisa Alcock et al.	Gait-related metabolic covariance networks at rest in Parkinson’s disease	2022
Professor David Brooks	Healthy brain aging assessed with [¹⁸F]FDG and [¹¹C]UCB-J PET	2022
Professor David Brooks	In vivo vesicular acetylcholine transporter density in human peripheral organs: an [¹⁸F]FEOBV PET/CT study	2022
Professor Nicola Pavese Professor David Brooks	Mapping Cholinergic Synaptic Loss in Parkinson's Disease: An [¹⁸F]FEOBV PET Case-Control Study	2022
Professor John O'Brien Professor John-Paul Taylor Professor David Brooks Professor Ian McKeith Professor Alison Yarnall et al.	RENEWAL: REpurposing study to find NEW compounds with Activity for Lewy body dementia—an international Delphi consensus	2022
Professor David Brooks	Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs	2022
Professor David Brooks	Trial of Cinpanemab in Early Parkinson’s Disease	2022
Professor David Brooks	Widespread cell stress and mitochondrial dysfunction in early Alzheimer’s Disease	2022
Professor David Brooks	Activated N-methyl-D-aspartate receptor ion channels detected in focal epilepsy with [¹⁸F]GE-179 positron emission tomography	2021
Professor Nicola Pavese Professor David Brooks	Brain microglial activation increased in glucocerebrosidase (GBA1) mutation carriers	2021
Professor David Brooks Dr Clive Ballard	Does insulin resistance influence neurodegeneration in non-diabetic Alzheimer’s subjects?	2021
Professor David Brooks	Exercise protects synaptic density in a rat model of Parkinson’s disease	2021
Professor David Brooks	Future imaging in dementia	2021
Professor David Brooks	Imaging Familial and Sporadic Neurodegenerative Disorders associated with Parkinsonism	2021
Professor David Brooks Professor Nicola Pavese	Impaired cerebral microcirculation in isolated rapid eye movement sleep behaviour disorder	2021
Professor David Brooks Professor Nicola Pavese	Impulse control disorders are associated with lower ventral striatum dopamine D3 receptor availability in Parkinson's disease: a [¹¹C]-PHNO PET study	2021
Professor David Brooks	In vivo imaging of synaptic SV2A protein density in healthy and striatal-lesioned rats with [11C]UCB-J PET	2021
Professor David Brooks Professor Nicola Pavese	Monocyte markers correlate with immune and neuronal brain changes in REM Sleep Behaviour Disorder	2021
Professor David Brooks	Neuroinflammation, functional connectivity and structural network integrity in the Alzheimer's spectrum	2021
Professor David Brooks	NMDA receptor ion channel activation detected in vivo with [¹⁸F]GE-179 PET after electrical stimulation of rat hippocampus	2021
Professor David Brooks	PET imaging reveals early and progressive dopaminergic deficits after intra-striatal injection of preformed alpha-synuclein fibrils in rats	2021
Professor Nicola Pavese Professor David Brooks	Preserved noradrenergic function in Parkinson´s disease patients with rest tremor	2021
Dr Kirstie Anderson Dr Rachael Lawson Professor David Brooks Professor Nicola Pavese	Progression of sleep disturbances in Parkinson’s Disease. A 5-year longitudinal study.	2021
Professor David Brooks	Reduced synaptic density in patients with Lewy body dementia: an [¹¹C]UCB-J PET imaging study	2021
Professor David Brooks	Regional locus coeruleus degeneration is uncoupled from noradrenergic terminal loss in Parkinson’s disease	2021
Dr Jacopo Pasquini Professor David Brooks Professor Nicola Pavese	The Cholinergic Brain in Parkinson's Disease	2021
Professor David Brooks	Activation of NMDA Receptor Ion Channels by Deep Brain Simulation in the Pig Visualised with[¹⁸F]GE-179 PET	2020
Professor Nicola Pavese Professor David Brooks	Altered sensorimotor cortex noradrenergic function in idiopathic REM sleep behaviour disorder – a PET study	2020
Professor David Brooks	Amyloid-PET and ¹⁸F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias	2020
Professor Nicola Pavese Professor David Brooks	Brain-first versus body-first Parkinson's disease: a multimodal imaging case-control study	2020
Professor Nicola Pavese Professor David Brooks	Brain-first vs. Body-first Parkinson’s disease: a multi-modal imaging case-control study	2020
Professor David Brooks	Can autonomic testing and imaging contribute to the early diagnosis of MSA? A systematic review and recommendations by the MDS multiple system atrophy (MoDiMSA) study group	2020
Professor David Brooks Professor Nicola Pavese	Cholinergic denervation in patients with idiopathic rapid eye movement sleep behaviour disorder	2020
Professor David Brooks	Cortical cholinergic dysfunction correlates with microglial activation in the substantia innominata in REM sleep behavior disorder	2020
Professor David Brooks	EANM practice guideline/SNMMI procedure standard for dopaminergic imaging in Parkinsonian syndromes 1.0	2020
Professor David Brooks	Erratum: Correction to: Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: study protocol for a randomised controlled trial (ELAD study) (Trials (2019) 20 1 (191))	2020
Professor David Brooks Professor Nicola Pavese	Imaging dopamine function and microglia in asymptomatic LRRK2 mutation carriers	2020
Rokiah Ismail Professor David Brooks	Impaired Perfusion And Capillary Dysfunction In Prodromal Alzhemer’s Disease	2020
Professor David Brooks	Low plasma neurofilament light levels associated with raised cortical microglial activation suggest inflammation acts to protect prodromal Alzheimer’s disease	2020
Professor David Brooks	Preclinical PET Studies of [¹¹C]UCB-J Binding in Minipig Brain	2020
Professor David Brooks	Tau Tangles in Parkinson’s Disease: A 2-Year Follow-Up Flortaucipir PET Study	2020
Professor David Brooks	The relationships between neuroinflammation, beta-amyloid and tau deposition in Alzheimer’s disease: a longitudinal PET study	2020
Professor David Brooks	Abnormal Amyloid Load in Mild Cognitive Impairment: The Effect of Reducing the PiB‐PET Threshold	2019
Professor David Brooks	Ageing and amyloidosis underlie the molecular and pathological alterations of tau in a mouse model of familial Alzheimer’s disease	2019
Professor David Brooks	Attenuation of dopamine-induced GABA release in problem gamblers	2019
Dr Rory Durcan Dr Lou Wiblin Professor Lynn Rochester Professor David Brooks Professor David Burn et al.	Clinical implications of early caudate dysfunction in Parkinson’s disease	2019
Professor David Brooks	Comment on "In Vivo [¹⁸F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates"	2019
Professor David Brooks	Confirmation of Specific Binding of the 18-kDa Translocator Protein (TSPO) Radioligand [¹⁸F]GE-180: a Blocking Study Using XBD173 in Multiple Sclerosis Normal Appearing White and Grey Matter	2019
Professor David Brooks	Dynamic ¹¹C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis	2019
Professor David Brooks	Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer's disease: Study protocol for a randomised controlled trial (ELAD study)	2019
Rob Atkinson Professor David Brooks	Microglial activation in early Alzheimer trajectory is associated with higher gray matter volume	2019
Dr Rory Durcan Dr Lou Wiblin Dr Rachael Lawson Dr Tien Kheng Khoo Professor Alison Yarnall et al.	Prevalence and duration of non‐motor symptoms in prodromal Parkinson's disease	2019
Professor David Brooks Professor Nicola Pavese	Progressive loss of raphe nuclei serotonin transporter in early Parkinson’s disease: a longitudinal ¹²³I-FP-CIT SPECT study	2019
Professor David Brooks	Tau Aggregation Correlates with Amyloid Deposition in Both Mild Cognitive Impairment and Alzheimer's Disease Subjects	2019
Professor David Brooks	Widespread microglial activation in multiple system atrophy	2019
Professor David Brooks	Decreased noradrenaline transporter density in the motor cortex of Parkinson's disease patients	2018
Professor David Brooks	Does inflammation precede tau aggregation in early Alzheimer's disease? A PET study	2018
Professor David Brooks	Evaluation of the noradrenergic system in Parkinson’s disease: an ¹¹C-MeNER PET and neuromelanin MRI study	2018
Professor David Brooks Professor Nicola Pavese	Extrastriatal monoaminergic dysfunction and enhanced microglial activation in idiopathic rapid eye movement sleep behaviour disorder	2018
Professor David Brooks	In vivo quantification of glial activation in minipigs overexpressing human α-synuclein	2018
Professor Nicola Pavese Professor David Brooks	In vivo staging of pathology in REM Sleep Behaviour Disorder – a multi-modality imaging case-control study	2018
Dr Michael Firbank Dr Rachael Lawson Professor Alison Yarnall Professor David Brooks Professor David Burn et al.	Longitudinal diffusion tensor imaging changes in early Parkinson’s disease: ICICLE-PD study	2018
Professor David Brooks	MAO-B Inhibitors Do Not Block In Vivo Flortaucipir ([¹⁸F]-AV-1451) Binding	2018
Professor David Brooks	Microglial activation correlates in vivo with both tau and amyloid in Alzheimer’s disease	2018
Professor David Brooks	Nigrostriatal proteasome inhibition impairs dopamine neurotransmission and motor function in minipigs	2018
Professor David Brooks	Observations on REM sleep without atonia assessed with a semi-automated scoring algorithm	2018
Dr Dag Aarsland Professor David Brooks	Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease	2018
Johann Pasquier Professor David Brooks Professor Nicola Pavese	Progression of tremor in early stages of Parkinson’s disease: a clinical and neuroimaging study	2018
Professor David Brooks	Recommendations of the Global Multiple System Atrophy Research Roadmap Meeting	2018
Professor David Brooks	Role of neuroinflammation in Alzheimer’s trajectory and in vivo quantification using PET	2018
Professor David Brooks	Simplifying [¹⁸F]GE-179 PET: are both arterial blood sampling and 90-min acquisitions essential?	2018
Professor David Brooks	Simplifying [¹⁸F]GE-179 PET: are both arterial blood sampling and 90-minute acquisitions essential?	2018
Professor David Brooks	The Effect of 40-Hz Light Therapy on Amyloid Load in Patients with Prodromal and Clinical Alzheimer’s Disease	2018
Professor David Brooks	The future of brain imaging in Parkinson’s disease	2018
Professor David Brooks Professor Nicola Pavese	Assessment of neuroinflammation in patients with idiopathic rapid-eye-movement sleep behaviour disorder: A case-control study	2017
Professor Nicola Pavese Professor David Brooks	Brain inflammation accompanies amyloid in a majority of mild cognitive impairment cases due to Alzheimer’s disease	2017
Dr Michael Firbank Professor Alison Yarnall Dr Rachael Lawson Dr Gordon Duncan Dr Tien Kheng Khoo et al.	Cerebral glucose metabolism and cognition in newly diagnosed Parkinson’s disease: ICICLE-PD study	2017
Professor David Brooks	In Vivo cortical tau in Parkinson's disease using 18F-AV-1451 positron emission tomography	2017
Dr Luis Peraza Rodriguez Dr Rachael Lawson Dr Gordon Duncan Professor Alison Yarnall Dr Michael Firbank et al.	Intra- and inter-network functional alterations in Parkinson's disease with mild cognitive impairment	2017
Dr Michael Firbank Dr Rachael Lawson Professor Alison Yarnall Dr Gordon Duncan Dr Tien Kheng Khoo et al.	Longitudinal whole-brain atrophy and ventricular enlargement in nondemented Parkinson's disease	2017
Professor David Burn Professor David Brooks	Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy	2017
Professor David Brooks	Suspected non Alzheimer's pathology – Is it non-Alzheimer's or non-amyloid?	2017
Professor Nicola Pavese Professor David Brooks	Sustained striatal dopamine levels following intestinal levodopa infusions in Parkinson's disease patients	2017
Professor David Brooks	Validation of an electronic image reader training programme for interpretation of [¹⁸F]flutemetamol β-amyloid PET brain images	2017
Professor David Brooks	In vivo imaging of neuromelanin in Parkinson's disease using ¹⁸F-AV-1451 PET	2016
Dr Gordon Duncan Dr Michael Firbank Professor Alison Yarnall Dr Tien Kheng Khoo Professor David Brooks et al.	Gray and white matter imaging: A biomarker for cognitive impairment in early Parkinson's disease?	2016
Professor David Burn Professor David Brooks	Hypothalamic volume loss is associated with reduced melatonin output in Parkinson's disease	2016
Professor David Brooks	Imaging Synucleinopathies	2016
Professor David Brooks	Imaging Systemic Dysfunction in Parkinson's Disease	2016
Professor David Brooks	Molecular imaging of dopamine transporters	2016
Dr Luis Peraza Rodriguez Dr Rachael Lawson Dr Michael Firbank Professor Alison Yarnall Professor David Brooks et al.	Principal component discriminant analysis of mild cognitive impairment in Parkinson’s disease reveals early functional changes in the resting state	2016
Professor David Brooks Professor Nicola Pavese	Sleep problems and hypothalamic dopamine D3 receptor availability in Parkinson disease	2016
Professor Alison Yarnall Dr Rachael Lawson Dr Gordon Duncan Dr Tien Kheng Khoo Professor David Brooks et al.	Anticholinergic Load: Is there a Cognitive Cost in Early Parkinson's Disease?	2015
Dr Michael Firbank Dr Rachael Lawson Professor Alison Yarnall Dr Tien Kheng Khoo Professor David Brooks et al.	Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study	2015
Dr Rachael Lawson Professor Alison Yarnall Dr Tien Kheng Khoo Professor David Brooks Professor David Burn et al.	Baseline and longitudinal grey matter changes in newly diagnosed Parkinson's disease: ICICLE-PD study	2015
Professor Alison Yarnall Dr Gordon Duncan Dr Shirley Coleman Dr Michael Firbank Professor Gavin Hudson et al.	Characterizing mild cognitive impairment in incident Parkinson disease The ICICLE-PD Study	2014
Dr Gordon Duncan Dr Tien Khoo Professor Alison Yarnall Dr Michael Firbank Professor Patrick Chinnery et al.	Genetic impact on cognition and brain function in newly diagnosed Parkinson's disease: ICICLE-PD study	2014
Dr Tien Khoo Professor Alison Yarnall Dr Gordon Duncan Dr Shirley Coleman Professor John O'Brien et al.	The spectrum of nonmotor symptoms in early Parkinson disease	2013
Professor Alison Yarnall Dr Tien Khoo Dr Gordon Duncan Professor David Brooks Professor David Burn et al.	Anti-cholinergic load: Is there a cognitive cost in early Parkinson’s disease?	2012
Dr Tien Kheng Khoo Dr Gordon Duncan Professor Alison Yarnall Professor David Brooks Professor John O'Brien et al.	Apathy in incident Parkinson’s disease	2012
Professor Alison Yarnall Professor Lynn Rochester Dr Gordon Duncan Dr Tien Kheng Khoo Professor David Brooks et al.	Cholinergic dysfunction in Parkinson’s disease with mild cognitive impairment: a short latency afferent inhibition study	2012
Dr Gordon Duncan Dr Tien Kheng Khoo Professor Alison Yarnall Professor John O'Brien Professor David Brooks et al.	Elevated homocysteine levels and cognitive dysfunction in an incident cohort of non-demented Parkinson’s disease patients.	2012
Professor David Brooks Professor David Burn	Updated guidelines for the management of Parkinson's disease	2001