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Browsing publications by Dr Julie Tucker

Newcastle AuthorsTitleYearFull text
Judith Unterlass
Dr Arnaud Basle
Dr Julie Tucker
Dr Celine Cano
Professor Martin Noble
et al.
Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer2018
Dr Julie Tucker
Keep it together: restraints in crystallographic refinement of macromolecule-ligand complexes2017
Judith Unterlass
Dr Arnaud Basle
Dr Julie Tucker
Dr Celine Cano
Professor Martin Noble
et al.
Structural insights into the enzymatic activity and potential substrate promiscuity of human 3-phosphoglycerate dehydrogenase (PHGDH)2017
Dr Julie Tucker
Professor Keith Jones
Discovery of 4,6-disubstituted pyrimidines as potent inhibitors of the Heat Shock Factor (HSF1) stress pathway and CDK92016
Dr Julie Tucker
Discovery of a novel allosteric inhibitor binding site in ERK5: comparison with canonical kinase hinge ATP-binding site2016
Dr Julie Tucker
First-in-Class Chemical Probes against Poly(ADP-ribose) Glycohydrolase (PARG) Inhibit DNA Repair with Differential Pharmacology to Olaparib2016
Dr Julie Tucker
Small Molecule Binding Sites on the Ras:SOS Complex Can Be Exploited for Inhibition of Ras Activation2015
Dr Julie Tucker
Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase2015
Dr Julie Tucker
Structure Guided Lead Generation for M. tuberculosis Thymidylate Kinase (Mtb TMK): Discovery of 3-Cyanopyridone and 1,6-Naphthyridin-2-one as Potent Inhibitors2015
Dr Julie Tucker
FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures.2014
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