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Browsing publications by Dr Jack Leslie.

Newcastle AuthorsTitleYearFull text
Toni Pringle
Erik Ramon Gil
Dr Jack Leslie
Professor Fiona Oakley
Professor Matthew Wright
et al.
Synthesis and Preclinical Evaluation of a 89Zr-labelled Human Single Chain Antibody for Non-invasive Detection of Hepatic Myofibroblasts in Acute Liver Injury2024
Rebecca Garnham
Dr Daniel Geh
Ryan Nelson
Erik Ramon Gil
Laura Wilson
et al.
ST3Gal1 synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer2023
Dr Sam Orange
Dr Jack Leslie
Professor Derek Mann
The exercise IL-6 enigma in cancer2023
Adnan Ali
Dr Caroline Wilson
Dr Jack Leslie
Professor Derek Mann
Author Correction: Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer (Nature Medicine, (2019), 25, 4, (641-655), 10.1038/s41591-019-0379-5)2022
Dr Suzanne Madgwick
Dr Saimir Luli
Helene Sellier
Dr Jacqueline Butterworth
Dr Jack Leslie
et al.
Claspin haploinsufficiency leads to defects in fertility, hyperplasia and an increased oncogenic potential2022
Dr Jack Leslie
Dr Jill Hunter
Amy Collins
Amelia Rushton
Lauren Russell
et al.
c-Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis2022
Dr Jack Leslie
Erik Ramon Gil
Kathryn Gilroy
Dr Saimir Luli
Maja Laszczewska
et al.
CXCR2 inhibition enables NASH-HCC immunotherapy2022
Dr Daniel Geh
Dr Jack Leslie
Professor Helen Reeves
Professor Derek Mann
Neutrophils as potential therapeutic targets in hepatocellular carcinoma2022
Dr Marco Zaki
Dr Sari Alhasan
Dr Ruchi Shukla
Misti McCain
Maja Laszczewska
et al.
Sulfatase-2 from Cancer Associated Fibroblasts: An Environmental Target for Hepatocellular Carcinoma?2022
Dr Jack Leslie
Dr Hannah Paish
Amy Collins
Rebecca Scott
Abi Watson
et al.
A Mammalian Target of Rapamycin-Perilipin 3 (mTORC1-Plin3) Pathway is essential to Activate Lipophagy and Protects Against Hepatosteatosis2021
Dr Jack Leslie
Dr Emma Scott
Professor Quentin Anstee
Professor Fiona Oakley
Lipid remodelling in hepatocyte proliferation and hepatocellular carcinoma 2021
Dr Jack Leslie
Dr Marie-Helene Ruchaud
Amy Collins
Leena Habiballa
Dr Gabi Saretzki
et al.
Neutrophils induce paracrine telomere dysfunction and senescence in ROS-dependent manner2021
Dr Jack Leslie
Stuart Robinson
Professor Fiona Oakley
Dr Saimir Luli
Non-invasive synchronous monitoring of neutrophil migration using whole body near-infrared fluorescence-based imaging2021
Dr Jack Leslie
Professor Fiona Oakley
Suppression of insulin-induced gene 1 (INSIG1) function promotes hepatic lipid remodelling and restrains NASH progression2021
Anna Smith
Dr Julia Whitehall
Carla Bradshaw
Dr Fiona Robertson
Dr Alasdair Blain
et al.
Age-associated mitochondrial DNA mutations cause metabolic remodeling that contributes to accelerated intestinal tumorigenesis2020
Dr Julie Worrell
Dr Jack Leslie
Dr Graham Smith
Marco Zaki
Dr Hannah Paish
et al.
cRel expression regulates distinct transcriptional and functional profiles driving fibroblast matrix production in systemic sclerosis2020
Dr Jack Leslie
Dr Marina Garcia Macia
Dr Saimir Luli
Dr Julie Worrell
William Reilly
et al.
c-Rel orchestrates energy-dependant epithelial and macrophage reprogramming in fibrosis2020
Dr Jack Leslie
Benjamin Millar
Alicia Del Carpio Pons
Rachel Burgoyne
Joseph Frost
et al.
FPR-1 is an important regulator of neutrophil recruitment and a tissue-specific driver of pulmonary fibrosis2020
Dr Jack Leslie
Professor Fiona Oakley
Loss of ELK1 has differential effects on age-dependent organ fibrosis2020
Dr Hannah Paish
Lee Reed
Helen Brown
Mark Bryan
Dr Olivier Govaere
et al.
A bioreactor technology for modelling fibrosis in human and rodent precision-cut liver slices2019
Dr Hannah Paish
Lee Reed
Abi Watson
Dr Jack Leslie
Professor Fiona Oakley
et al.
Ammonia Scavenging Prevents Progression of Fibrosis in Experimental Nonalcoholic Fatty Liver Disease2019
Dr Dumitru Sirbu
Dr Saimir Luli
Dr Jack Leslie
Professor Fiona Oakley
Professor Andrew Benniston
et al.
Enhanced in vivo Optical Imaging of the Inflammatory Response to Acute Liver Injury in C57BL/6 Mice using a Highly Bright Near-Infrared BODIPY Dye2019
Dr Caroline Wilson
Dr Jack Leslie
Professor Derek Mann
Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer2019
Dr Mujdat Zeybel
Dr Saimir Luli
Laura Sabater
Dr Timothy Hardy
Professor Fiona Oakley
et al.
A Proof-of-Concept for Epigenetic Therapy of Tissue Fibrosis: Inhibition of Liver Fibrosis Progression by 3-Deazaneplanocin A2017
Dr Anna Moles Fernandez
Dr Jacqueline Butterworth
Dr Jill Hunter
Dr Jack Leslie
Helene Sellier
et al.
A RelA(p65) Thr505 phospho-site mutation reveals an important mechanism regulating NF-kB dependent liver regeneration and cancer2016