Publications by Professor Akane Kawamura - ePrints

Browsing publications by Professor Akane Kawamura.

Newcastle Authors	Title	Year
Professor Akane Kawamura	Cyclic β^2,3-amino acids improve the serum stability of macrocyclic peptide inhibitors targeting the SARS-CoV-2 main protease	2024
Dr Roman Belle Dr Hilal Sarac Dr Grace Roper Professor Akane Kawamura	Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate	2024
Tom Smith Professor Akane Kawamura	Identification and engineering of potent cyclic peptides with selective or promiscuous binding through biochemical profiling and bioinformatic data analysis	2024
Klemensas Simelis Dr Hilal Sarac Dr Tom McAllister Dr Roman Belle Professor Akane Kawamura et al.	Selective targeting of human TET1 by cyclic peptide inhibitors: Insights from biochemical profiling	2024
Dr Oliver Coleman Dr Tom McAllister Siddique Amin Professor Akane Kawamura	Cyclic peptides target the aromatic cage of a PHD-finger reader domain to modulate epigenetic protein function	2023
Catherine Salvini Benoit Darlot Jack Davison Dr Mathew Martin Dr Susan Tudhope et al.	Fragment expansion with NUDELs – poised DNA-encoded libraries	2023
Professor Akane Kawamura	In vitro selection of macrocyclic peptide inhibitors containing cyclic γ^2,4-amino acids targeting the SARS-CoV-2 main protease	2023
Dr Joanna Bonnici Professor Akane Kawamura	The catalytic domains of all human KDM5 JmjC demethylases catalyse N-methyl arginine demethylation	2023
Dr Oliver Coleman Professor Akane Kawamura	An integrated platform approach enables discovery of potent, selective and ligand-competitive cyclic peptides targeting the GIP receptor	2022
Professor Akane Kawamura	Increasing Diversity in Admissions to Postgraduate Study	2022
Dr Roman Belle Dr Vinod Kumar Professor Akane Kawamura	Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins	2022
Toni Pringle Dr Oliver Coleman Professor Akane Kawamura Dr James Knight	The influence of degree of labelling upon cellular internalisation of antibody-cell penetrating peptide conjugates	2022
Professor Akane Kawamura	Hypoxia and hypoxia mimetics differentially modulate histone post-translational modifications	2021
Dr Tom McAllister Professor Akane Kawamura	Structural diversity in de novo cyclic peptide ligands from genetically encoded library technologies	2021
Professor Akane Kawamura	Chemical compounds targeting DNA methylation and hydroxymethylation	2020
Professor Akane Kawamura	Cyclic Peptides as Chemical Probes	2020
Professor Akane Kawamura	Engineered anti-inflammatory peptides inspired by mapping an evasin-chemokine interaction	2020
Professor Akane Kawamura	Epigenetics equals chemical biology	2020
Professor Akane Kawamura	Inhibitors of JmjC-containing Histone Demethylases: Structural Perspective	2020
Professor Akane Kawamura	Light-driven post-translational installation of reactive protein side chains	2020
Professor Akane Kawamura	Metampicillin is a Cyclic Aminal Produced by Reaction of Ampicillin With Formaldehyde	2020
Dr Hilal Sarac Professor Akane Kawamura	Systematic characterization of chromatin modifying enzymes identifies KDM3B as a critical regulator in castration resistant prostate cancer	2020
Dr Tom McAllister Professor Akane Kawamura	Use of Cyclic Peptides to Induce Crystallization – Case Study with Prolyl Hydroxylase Domain 2	2020
Professor Akane Kawamura	Using evasins to target the chemokine network in inflammation	2020
Professor Akane Kawamura	A knottin scaffold directs the CXC-chemokine-binding specificity of tick evasins	2019
Professor Akane Kawamura	Corrigendum to “Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A” (Bioorganic & Medicinal Chemistry (2018) 26(6) (1225–1231), (S0968089617318497) (10.1016/j.bmc.2018.01.013))	2019
Professor Akane Kawamura	Design, Synthesis and Characterization of Covalent KDM5 Inhibitors	2019
Professor Akane Kawamura	Formaldehyde quantification using ampicillin is not selective	2019
Professor Akane Kawamura	JmjC-domain-Containing Histone Demethylases	2019
Professor Akane Kawamura	The Clinically Used Iron Chelator Deferasirox Is an Inhibitor of Epigenetic JumonjiC Domain-Containing Histone Demethylases	2019
Dr Tom McAllister Professor Akane Kawamura	2-Oxoglutarate regulates binding of hydroxylated hypoxia-inducible factor to prolyl hydroxylase domain 2	2018
Professor Akane Kawamura	Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets	2018
Professor Akane Kawamura	Human histone demethylase KDM6B can catalyse sequential oxidations	2018
Professor Akane Kawamura	In vitro enzyme assays for jmjC-domain-containing lysine histone demethylases (JmjC-KDMs)	2018
Professor Akane Kawamura	Inhibitors of both the N-methyl lysyl- and arginyl-demethylase activities of the JmjC oxygenases	2018
Professor Akane Kawamura	Investigations on small molecule inhibitors targeting the histone H3K4 tri-methyllysine binding PHD-finger of JmjC histone demethylases	2018
Professor Akane Kawamura	Lysine-241 Has a Role in Coupling 2OG Turnover with Substrate Oxidation During KDM4-Catalysed Histone Demethylation	2018
Professor Akane Kawamura	Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26	2018
Dr Tom McAllister Professor Akane Kawamura	Non-competitive cyclic peptides for targeting enzyme-substrate complexes	2018
Professor Akane Kawamura	Structure-activity studies of a macrocyclic peptide inhibitor of histone lysine demethylase 4A	2018
Professor Akane Kawamura	Synthesis and Biological Evaluation of Tripartin, a Putative KDM4 Natural Product Inhibitor, and 1-Dichloromethylinden-1-ol Analogues	2018
Professor Akane Kawamura	The N-terminal domain of a tick evasin is critical for chemokine binding and neutralization and confers specific binding activity to other evasins	2018
Professor Akane Kawamura	Thioether Macrocyclic Peptides Selected against TET1 Compact Catalytic Domain Inhibit TET1 Catalytic Activity	2018
Professor Akane Kawamura	Assessing histone demethylase inhibitors in cells: Lessons learned	2017
Professor Akane Kawamura	Discovery of a Highly Selective Cell-Active Inhibitor of the Histone Lysine Demethylases KDM2/7	2017
Professor Akane Kawamura	Highly selective inhibition of histone demethylases by de novo macrocyclic peptides	2017
Professor Akane Kawamura	Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition	2017
Professor Akane Kawamura	KDM3A coordinates actin dynamics with intraflagellar transport to regulate cilia stability	2017
Dr Tom McAllister Professor Akane Kawamura	KDM4A regulates HIF-1 levels through H3K9me3	2017
Professor Akane Kawamura	Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials	2017
Professor Akane Kawamura	Potent and Selective KDM5 Inhibitor Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells	2017
Professor Akane Kawamura	Selective recognition of the di/trimethylammonium motif by an artificial carboxycalixarene receptor	2017
Professor Akane Kawamura	Studies on the Interaction of the Histone Demethylase KDM5B with Tricarboxylic Acid Cycle Intermediates	2017
Professor Akane Kawamura	The Activity of JmjC Histone Lysine Demethylase KDM4A is Highly Sensitive to Oxygen Concentrations	2017
Professor Akane Kawamura	Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities	2017
Professor Akane Kawamura	8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors	2016
Professor Akane Kawamura	Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases	2016
Dr Tom McAllister Professor Akane Kawamura	Recent Progress in Histone Demethylase Inhibitors	2016
Professor Akane Kawamura	Tetracyanoresorcin[4]arene selectively recognises trimethyllysine and inhibits its enzyme-catalysed demethylation	2016
Professor Akane Kawamura	Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases	2015
Professor Akane Kawamura	Epigenetic regulation by histone demethylases in hypoxia	2015
Professor Akane Kawamura	Potent and selective triazole-based inhibitors of the hypoxia-inducible factor prolyl-hydroxylases with activity in the murine brain	2015
Professor Akane Kawamura	A cell-permeable ester derivative of the JmjC histone demethylase inhibitor IOX1	2014
Professor Akane Kawamura	Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 defined by substrate specificity and inhibitor binding	2014
Professor Akane Kawamura	Modulating carnitine levels by targeting its biosynthesis-selective inhibition of γ-butyrobetaine hydroxylase	2014
Professor Akane Kawamura	Non-enzymatic chemistry enables 2-hydroxyglutarate-mediated activation of 2-oxoglutarate oxygenases	2014
Professor Akane Kawamura	Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor	2014
Professor Akane Kawamura	Pan-histone demethylase inhibitors simultaneously targeting Jumonji C and lysine-specific demethylases display high anticancer activities	2014
Professor Akane Kawamura	Rhodanine hydrolysis leads to potent thioenolate mediated metallo-β-lactamase inhibition	2014
Professor Akane Kawamura	Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates	2014
Professor Akane Kawamura	Targeting histone lysine demethylases - Progress, challenges, and the future	2014
Dr Paul Brennan Professor Akane Kawamura	5-Carboxy-8-hydroxyquinoline is a broad spectrum 2-oxoglutarate oxygenase inhibitor which causes iron translocation	2013
Professor Akane Kawamura	Identification of the KDM2/7 histone lysine demethylase subfamily inhibitor and its antiproliferative activity	2013
Professor Akane Kawamura	Is JmjC Oxygenase Catalysis Limited to Demethylation?	2013