Publications by Dr Jim Stewart - ePrints

Browsing publications by Dr Jim Stewart.

Newcastle Authors	Title	Year
Dr Jim Stewart	mitoTALEN Eliminates Mutant mtDNA Genomes in Neurons	2024
Dr Jim Stewart Professor Patrick Chinnery	Cell lineage-specific mitochondrial resilience during mammalian organogenesis	2023
Dr Jim Stewart	Cultured lymphocytes’ mitochondrial genome integrity is not altered by cladribine	2023
Dr Jim Stewart Professor Patrick Chinnery	High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life	2023
Dr Jim Stewart	Large dataset of octocoral mitochondrial genomes provides new insights into mt-mutS evolution and function	2022
Dr Jim Stewart	The [PSI+] prion and HSP104 modulate cytochrome c oxidase deficiency caused by deletion of COX12	2022
Dr Jim Stewart	A Mitochondrial Targeted Meganuclease Eliminates Mutant Mitochondrial DNA in a Mouse Model	2021
Dr Jim Stewart	Current Progress with Mammalian Models of Mitochondrial DNA Disease	2021
Dr Jim Stewart Professor Patrick Chinnery	Extreme heterogeneity of human mitochondrial DNA from organelles to populations	2021
Dr Jim Stewart	High throughput detection of mtDNA mutations leading to tRNA processing errors	2021
Dr Jim Stewart	Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission	2021
Dr Jim Stewart	Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing	2020
Dr Jim Stewart	Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse	2019
Dr Laura Greaves Professor Robert Taylor Dr Jim Stewart	A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency	2018
Dr Jim Stewart	Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice	2018
Dr Jim Stewart	Delivery of mtZFNs into Early Mouse Embryos	2018
Dr Jim Stewart	Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo	2018
Dr Thomas Nicholls Dr Jim Stewart	Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria	2018
Dr Jim Stewart	MitoTALEN reduces mutant mtDNA load and restores tRNA^Ala levels in a mouse model of heteroplasmic mtDNA mutation	2018
Dr Jim Stewart	Increased total mtDNA copy number cures male infertility despite unaltered mtDNA mutation load	2017
Holly Baines Dr Craig Stamp Dr Laura Greaves Dr Jim Stewart	A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease	2016
Dr Jim Stewart	Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly	2016
Dr Jim Stewart	Tissue-specific modulation of mitochondrial DNA segregation by a defect in mitochondrial division	2016
Dr Jim Stewart	Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies	2015
Dr Jim Stewart	Mitochondrial DNA: Radically free of free-radical driven mutations	2015
Dr Jim Stewart	Simultaneous DNA and RNA Mapping of Somatic Mitochondrial Mutations across Diverse Human Cancers	2015
Dr Jim Stewart Professor Patrick Chinnery	The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease	2015
Dr Jim Stewart	The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication	2015
Dr Jim Stewart	Addressing RNA integrity to determine the impact of mitochondrial DNA mutations on brain mitochondrial function with age	2014
Dr Jim Stewart	Keeping mtDNA in shape between generations	2014
Dr Jim Stewart	No recombination of mtDNA after heteroplasmy for 50 generations in the mouse maternal germline	2014
Holly Baines Dr Jim Stewart Craig Stamp Dr Anze Zupanic Emeritus Professor Thomas Kirkwood et al.	Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans	2014
Professor Patrick Chinnery Dr Lyndsey Butterworth Dr Jim Stewart Professor Mary Herbert Emeritus Professor Doug Turnbull et al.	The Challenges of Mitochondrial Replacement	2014
Christoph Freyer Dr Lynsey Cree Dr Jim Stewart Dr Vasileios Floros Dr David Samuels et al.	Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission	2012
Dr Jim Stewart Dr Joanna Elson	Purifying selection of mtDNA and its implications for understanding evolution and mitochondrial disease	2008