Publications by Emeritus Professor Paul Flecknell - ePrints

Browsing publications by Emeritus Professor Paul Flecknell.

Newcastle Authors	Title	Year
Dr Amy Miller Dr Jasmine Clarkson Emma Geijer Simpson Emeritus Professor Paul Flecknell Dr Matthew Leach et al.	Evaluating pain and analgesia effectiveness following routine castration in rabbits using behaviour and facial expressions	2022
Henri Bertrand Emeritus Professor Paul Flecknell	A cervical mass in a laboratory rhesus macaque (Macaca mulatta): Suspicion of air sacculitis	2021
Henri Bertrand Professor Stuart Baker Emeritus Professor Paul Flecknell	Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (Macaca mulatta)	2021
Dr Jasmine Clarkson Dr Matthew Leach Emeritus Professor Paul Flecknell Professor Candy Rowe	Negative mood affects the expression of negative but not positive emotions in mice.	2020
Emeritus Professor Paul Flecknell	Welfare Impact of Carbon Dioxide Euthanasia on Laboratory Mice and Rats: A Systematic Review	2020
Dr Matthew Leach Emeritus Professor Paul Flecknell Dr Claire Witham	Opportunities for Refinement in Neuroscience: Indicators of Wellness and Post-operative Pain in Laboratory Macaques1	2019
Dr Colline Poirier Caitlin Oliver Janire Castellano Bueno Emeritus Professor Paul Flecknell Professor Melissa Bateson et al.	Pacing behaviour in laboratory macaques is an unreliable indicator of acute stress	2019
Dr Jenny Lofgren Dr Amy Miller Carla Bradshaw Emeritus Professor Paul Flecknell Dr Johnny Roughan et al.	Analgesics promote welfare and sustain tumour growth in orthotopic 4T1 and B16 mouse cancer models	2018
Dr Jasmine Clarkson Emeritus Professor Paul Flecknell Dr Matthew Leach Professor Candy Rowe	Handling method alters the hedonic value of reward in laboratory mice	2018
Henri Bertrand Emeritus Professor Paul Flecknell	Reported analgesic and anaesthetic administration to non-human primates undergoing experimental surgical procedure: 2010-2015	2018
Henri Bertrand Charlotte Sanders Emeritus Professor Paul Flecknell	The use of desflurane for neurosurgical procedures in rhesus macaque (Macaca mulatta)	2018
Henri Bertrand Charlotte Sanders Jennifer Murray Emeritus Professor Paul Flecknell	A combination of alfaxalone, medetomidine and midazolam for the chemical immobilization of Rhesus macaque (Macaca mulatta): Preliminary results	2017
Emeritus Professor Paul Flecknell Dr Aurelie Thomas	Comparative Anesthesia and Analgesia of Laboratory Animals	2017
Henri Bertrand Svenja Springer Emeritus Professor Paul Flecknell	Comparison of emergence times and quality between isoflurane and sevoflurane in rhesus macaque (Macaca mulatta) undergoing neurosurgical procedure	2017
Dr Aurelie Thomas Emeritus Professor Paul Flecknell	Minimally invasive technique for intrathecal administration of morphine in rats: practicality and antinociceptive properties	2017
Henri Bertrand Emeritus Professor Paul Flecknell	Preliminary assessment of midazolam, fentanyl and fluanisone combination for the sedation of rhesus macaques (Macaca mulatta)	2017
Emeritus Professor Paul Flecknell	Translational pain assessment: Could natural animal models be the missing link?	2017
Henri Bertrand Dr Aurelie Thomas Yvette Ellen Robert Dorward Emeritus Professor Paul Flecknell et al.	A surgical approach in the treatment of preputial gland abscesses in mice	2016
Henri Bertrand Yvette Ellen Stevie O'Keefe Emeritus Professor Paul Flecknell	Comparison of the effects of ketamine and fentanyl-midazolam-medetomidine for sedation of rhesus macaques (Macaca mulatta)	2016
Dr Aurelie Thomas Dr Amy Miller Dr Johnny Roughan Emeritus Professor Paul Flecknell	Efficacy of intrathecal morphine in a model of surgical pain in rats	2016
Emeritus Professor Paul Flecknell	Enhancing collaboration in the UK animal welfare research community	2016
Yvette Ellen Emeritus Professor Paul Flecknell Dr Matthew Leach	Evaluation of Using Behavioural Changes to Assess Post-Operative Pain in the Guinea Pig (Cavia porcellus)	2016
Emeritus Professor Paul Flecknell	Hospice and palliative care	2016
Emeritus Professor Paul Flecknell	Opportunities for improving animal welfare in rodent models of epilepsy and seizures	2016
Dr Helen Gray Henri Bertrand Claire Mindus Emeritus Professor Paul Flecknell Professor Candy Rowe et al.	Physiological, behavioral, and scientific impact of different fluid control protocols in the rhesus macaque (Macaca mulatta)	2016
Dr Amy Miller Ben Skalkoyannis Emeritus Professor Paul Flecknell Dr Matthew Leach	Using the mouse grimace scale and behaviour to assess pain in CBA mice following vasectomy	2016
Emeritus Professor Paul Flecknell Dr Jenny Lofgren	Chapter 24 - Preanesthesia, Anesthesia, Analgesia, and Euthanasia	2015
Dr Simon Hill Professor Simon Thomas Emeritus Professor Paul Flecknell Dr Aurelie Thomas Dr Christopher Morris et al.	Rapid and equivalent systemic bioavailability of the antidotes HI-6 and dicobalt edetate via the intraosseous and intravenous routes	2015
Aimen Amer Dr Phillip Probert Dr Michael Dunn Margaret Knight Dr Abigail Vallance et al.	Sustained Isoprostane E2 Elevation, Inflammation and Fibrosis after Acute Ischaemia-Reperfusion Injury Are Reduced by Pregnane X Receptor Activation	2015
Dr Malcolm Coulthard Dr Clive Griffiths Dr Michael Drinnan Professor John Matthews Emeritus Professor Paul Flecknell et al.	Haemodialysing babies weighing <8 kg with the Newcastle infant dialysis and ultrafiltration system (Nidus): comparison with peritoneal and conventional haemodialysis	2014
Dr Johnny Roughan Claire Coulter Emeritus Professor Paul Flecknell Huw Thomas	The Conditioned Place Preference Test for Assessing Welfare Consequences and Potential Refinements in a Mouse Bladder Cancer Model	2014
Emeritus Professor Paul Flecknell Dr Aurelie Thomas	A comparison of medetomidine and its active enantiomer dexmedetomidine when administered with ketamine in mice	2013
Graciela Rocha Dr Johnny Roughan Dr Matthew Leach Emeritus Professor Paul Flecknell Professor Colin Ingram et al.	Antinociceptive Activities of Hyptis crenata Pohl	2013
Siân Wright-Williams Emeritus Professor Paul Flecknell Dr Johnny Roughan	Comparative Effects of Vasectomy Surgery and Buprenorphine Treatment on Faecal Corticosterone Concentrations and Behaviour Assessed by Manual and Automated Analysis Methods in C57 and C3H Mice	2013
Dr Amy Miller Siân Wright-Williams Emeritus Professor Paul Flecknell Dr Johnny Roughan	A comparison of abdominal and scrotal approach methods of vasectomy and the influence of analgesic treatment in laboratory mice	2012
Dr Aurelie Thomas Dr Matthew Leach Emeritus Professor Paul Flecknell	An alternative method of endotracheal intubation of common marmosets (Callithrix jacchus).	2012
Dr Matthew Leach Kristel Klaus Dr Amy Miller Emeritus Professor Paul Flecknell	Are we looking in the right place? - Implications for assessing pain	2012
Dr Aurelie Thomas Emeritus Professor Paul Flecknell Dr Huw Golledge	Combining Nitrous Oxide with Carbon Dioxide decreases the time to loss of consciousness during euthanasia in mice — refinement of animal welfare?	2012
Dr Stephanie Keating Dr Aurelie Thomas Emeritus Professor Paul Flecknell Dr Matthew Leach	Evaluation of EMLA Cream for Preventing Pain during Tattooing of Rabbits: Changes in Physiological, Behavioural and Facial Expression Responses	2012
Veronique Brieuc Emeritus Professor Paul Flecknell Dr Amy Miller Dr Matthew Leach	Peut-on utilliser les expressions faciales pour étudier la douleur chez les rongeurs? (Can we use facial expressions to study pain in rodents?)	2012
Emeritus Professor Paul Flecknell	Response to Westlund's commentary: 'Can conditioned reinforcers and variable-Ratio Schedules make food- and fluid control redundant?'	2012
Dr Matthew Leach Dr Amy Miller Emeritus Professor Paul Flecknell	The Assessment of Post-Vasectomy Pain in Mice using Behaviour and the Mouse Grimace Scale	2012
Dr Amy Miller Emeritus Professor Paul Flecknell Dr Matthew Leach Dr Johnny Roughan	A comparison of a manual and an automated behavioural analysis method for assessing post-operative pain in mice	2011
Susan Stamp Dr Kathryn White Dr Katrina Wood Dr Aurelie Thomas Annie Russell et al.	A novel perfusion fluid for DCD donor kidneys; better as a flush or a storage medium?	2011
Emeritus Professor Paul Flecknell Dr Matthew Leach Professor Melissa Bateson	Affective state and quality of life in mice	2011
Dr Matthew Leach Claire Coulter Dr Claire Richardson Emeritus Professor Paul Flecknell	Are We Looking in the Wrong Place? Implications for Behavioural-Based Pain Assessment in Rabbits (Oryctolagus cuniculi) and Beyond?	2011
Dr Chris Ray Susan Stamp Dr Kathryn White Dr Katrina Wood Dr Aurelie Thomas et al.	Large animal renal allotransplantation; a porcine recovery model to assess delayed graft function	2011
Emeritus Professor Paul Flecknell Dr Matthew Leach Dr Claire Richardson	Reported analgesic administration to rabbits undergoing experimental surgical procedures	2011
Dr Huw Golledge Emeritus Professor Paul Flecknell	The effect of behavioural state and cage environment on responses to euthanasia with isoﬂurane or carbon dioxide in BALB/c mice	2011
Dr Matthew Leach Dr Amy Miller Dr Johnny Roughan Emeritus Professor Paul Flecknell	A preliminary investigation into the practicality of use and duration of action of slow-release preparations of morphine and hydromorphone in laboratory rats	2010
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Anaesthesia with a combination of ketamine and medetomidine in the rabbit: effect of premedication with buprenorphine	2010
Steven White Professor James Shaw Emeritus Professor Paul Flecknell Professor Alastair Burt Professor Matthew Wright et al.	Chronic elevated systemic glucocorticoid results in widespread pancreatic-hepatic trans-differentiation in vivo	2010
Dr Karen Wallace Emeritus Professor Paul Flecknell Professor Alastair Burt Professor Matthew Wright	Disrupted Pancreatic Exocrine Differentiation and Malabsorption in Response to Chronic Elevated Systemic Glucocorticoid	2010
Emeritus Professor Paul Flecknell	Do mice have a pain face?	2010
Dr Matthew Leach Alison Forrester Emeritus Professor Paul Flecknell	Influence of preferred foodstuffs on the antinociceptive effects of orally administered buprenorphine in laboratory rats	2010
Dr Amy Miller Dr Matthew Leach Emeritus Professor Paul Flecknell	Mesure de la fiabilité et de la precision des expressions facials pour évaluer la douler chez la souris	2010
Emeritus Professor Paul Flecknell	Refinement of the use of food and fluid control as motivational tools for macaques used in behavioural neuroscience research Report of a Working Group of the NC3Rs	2010
Dr Matthew Leach Emeritus Professor Paul Flecknell	The use of propofol and sevoflurane for surgical anaesthesia in New Zealand White rabbits	2010
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Automated analysis of postoperative behaviour: assessment of HomeCageScan as a novel method to rapidly identify pain and analgesic effects in mice	2009
Dr Matthew Leach Dr Claire Richardson Dr Johnny Roughan Emeritus Professor Paul Flecknell	Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits	2009
Dr Matthew Leach Dr Claire Richardson Dr Johnny Roughan Emeritus Professor Paul Flecknell	Identifying potential behavioural indicators of pain in rabbits following ovariohysterectomy - Preliminary study	2009
Dr Amy Miller Dr Matthew Leach Emeritus Professor Paul Flecknell	Influence of early neonatal experience on nociceptive responses and analgesic effects in rats	2009
Emeritus Professor Paul Flecknell	Laboratory Animal Anaesthesia	2009
Claire Coulter Emeritus Professor Paul Flecknell Dr Claire Richardson	Reported analgesic administration to rabbits, pigs, sheep, dogs and non-human primates undergoing experimental surgical procedures	2009
Emeritus Professor Paul Flecknell Dr Claire Richardson	Reported analgesic and anaesthetic administration to rodents undergoing experimental surgical procedures	2009
Dr Amy Miller Dr Matthew Leach Emeritus Professor Paul Flecknell	The analgesic effects of oral paracetamol in two strains of mice undergoing vasectomy	2009
Graciela Rocha Dr Johnny Roughan Dr Matthew Leach Emeritus Professor Paul Flecknell Professor Colin Ingram et al.	Traditional use, chemical analysis and antinociceptive effects of Hyptis crenato Pohl	2009
Emeritus Professor Paul Flecknell	Analgesia from a veterinary perspective	2008
Emeritus Professor Paul Flecknell Jon Gledhill Dr Claire Richardson	Assessing animal health and welfare and recognising pain and distress	2007
Dr Claire Richardson Dr Johnny Roughan Emeritus Professor Paul Flecknell	Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse	2007
Dr Claire Richardson Lee Niel Dr Matthew Leach Emeritus Professor Paul Flecknell	Evaluation of the efficacy of a novel electronic pain assessment device, the Pain Gauge®, for measuring postoperative pain in rats	2007
Emeritus Professor Paul Flecknell Dr Claire Richardson	Laboratory Animals	2007
Emeritus Professor Paul Flecknell	Assessing the welfare of genetically altered mice	2006
Dr Huw Golledge Dr Matthew Leach Emeritus Professor Paul Flecknell	Newcastle Consensus Meeting on Carbon Dioxide Euthanasia of Laboratory Animals	2006
Dr Claire Richardson Emeritus Professor Paul Flecknell	Routine neutering of rabbits and rodents	2006
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Training in behaviour-based post-operative pain scoring in rats - An evaluation based on improved recognition of analgesic requirements	2006
Dr Claire Richardson Emeritus Professor Paul Flecknell	Anaesthesia and post-operative analgesia following experimental surgery in laboratory rodents: Are we making progress?	2005
Hannah Orr Dr Johnny Roughan Emeritus Professor Paul Flecknell	Assessment of ketamine and medetomidine anaesthesia in the domestic rabbit	2005
Rakesh Rai Emeritus Professor Paul Flecknell Dr Claire Richardson Professor Derek Manas	Creation of porcine liver tumor using human hepatoma cell lines: Experimental study	2005
Emeritus Professor Paul Flecknell	Partnerships for progress	2005
Dr Claire Richardson Emeritus Professor Paul Flecknell Dr Helen Robertson Professor Alastair Burt Professor Derek Manas et al.	Study of apoptosis and heat shock protein (HSP) expression in hepatocytes following radiofrequency ablation (RFA)	2005
Dr Nilofer Sabrine Dr Johnny Roughan Emeritus Professor Paul Flecknell	[abstract] Assessment of post-operative pain in infants and neonates	2004
Emeritus Professor Paul Flecknell	Assessing and managing pain and distress for ethics committees	2004
Emeritus Professor Paul Flecknell Dr Johnny Roughan	Assessing pain in animals - Putting research into practice	2004
Dr Johnny Roughan Emeritus Professor Paul Flecknell Dr Barry Davies	Behavioural assessment of the effects of tumour growth in rats and the influence of tne analgesics carprofen and meloxicam	2004
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Behaviour-based assessment of the duration of laparotomy-induced abdominal pain and the analgesic effects of carprofen and buprenorphine in rats	2004
Luis Antunes Dr Huw Golledge Dr Johnny Roughan Emeritus Professor Paul Flecknell	Comparison of electroencephalogram activity and auditory evoked responses during isoflurane and halothane anaesthesia in the rat	2003
Luis Antunes Dr Johnny Roughan Emeritus Professor Paul Flecknell	Effects of different propofol infusion rates on EEG activity and AEP responses in rats	2003
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Evaluation of a short duration behaviour-based post-operative pain scoring system in rats	2003
Luis Antunes Dr Johnny Roughan Emeritus Professor Paul Flecknell	Excitatory effects of fentanyl upon the rat electroencephalogram and auditory-evoked potential responses during anaesthesia	2003
Professor Simi Ali Emeritus Professor John Kirby Emeritus Professor Paul Flecknell Professor John Dark	Improvements in lung compliance after pulmonary transplantation: Correlation with interleukin 8 expression	2003
Dr Doug Aitchison Hannah Orr Emeritus Professor Paul Flecknell Emeritus Professor John Kirby Professor John Dark et al.	Nitric oxide during perfusion improves posttransplantation function of non-heart-beating donor lungs	2003
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Pain assessment and control in laboratory animals	2003
Emeritus Professor Paul Flecknell Professor John Dark	Pentoxifylline is as effective as leukocyte depletion for modulating pulmonary reperfusion injury	2003
Hannah Orr Dr Johnny Roughan Luis Antunes Emeritus Professor Paul Flecknell	Anaesthesia with ketamine/medetomidine in the rabbit: influence of route of administration and the effect of combination with butorphanol	2002
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Buprenorphine: a reappraisal of its antinociceptive effects and therapeutic use in alleviating post-operative pain in animals	2002
Emeritus Professor Paul Flecknell Professor Jonathan Rees	Production of acute and chronic itch with histamine and contact sensitizers in the mouse and guinea pig	2002
Dr Malcolm Coulthard Emeritus Professor Paul Flecknell Hannah Orr Professor Derek Manas Dr Marie O'Donnell et al.	Renal scaring caused by vesicoureteric reflux and urinary infection: A study in pigs	2002
Emeritus Professor Paul Flecknell	Replacement, reduction and refinement	2002
Emeritus Professor Paul Flecknell	Replacement, reduction and refinement	2002
Diana Levett Emeritus Professor Paul Flecknell Professor David Neal Kilian Mellon Dr Barry Davies et al.	Transfection of S100A4 produces metastatic variants of an orthotopic model of bladder cancer	2002
Emeritus Professor Paul Flecknell	Analgesia of small mammals	2001
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Behavioural effects of laparotomy and analgesic effects of ketoprofen and carprofen in rats	2001
Dr Doug Aitchison Hannah Orr Emeritus Professor Paul Flecknell Emeritus Professor John Kirby Professor John Dark et al.	Functional assessment of non-heart-beating donor lungs: Prediction of post-transplant function	2001
Dr Johnny Roughan Luis Antunes Hannah Orr Emeritus Professor Paul Flecknell	Induction of anaesthesia with desflurane and isoflurane in the rabbit	2001
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Effects of repeated anaesthesia with ketamine/medetomidine and of pre-anaesthetic administration of buprenorphine in rats	2000
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Effects of surgery and analgesic administration on spontaneous behaviour in singly housed rats	2000
Emeritus Professor Paul Flecknell	Pain Management in Animals	2000
Dr Johnny Roughan Emeritus Professor Paul Flecknell	Sufentanil and medetomidine anaesthesia in the rat and its reversal with atipamezole and butorphanol	2000
Dr Gavin Clowry Emeritus Professor Paul Flecknell	The successful use of fentanyl/fluanisone ('Hypnorm') as an anaesthetic for intracranial surgery in neonatal rats	2000
Emeritus Professor Paul Flecknell	A comparison of pre- and post-surgical administration of bupivacaine or buprenorphine following laparotomy in the rat	1999
Stephen Clark Dr Johnny Roughan Emeritus Professor Paul Flecknell Professor John Dark	A new porcine model of reperfusion injury after lung transplantation	1999
Emeritus Professor Paul Flecknell Hannah Orr Dr Johnny Roughan Robert Stewart	Comparison of the effects of oral or subcutaneous carprofen or ketoprofen in rats undergoing laparotomy.	1999
Emeritus Professor Paul Flecknell Dr Johnny Roughan	Induction of anaesthesia with sevoflurane and isoflurane in the rabbit	1999
Dr Johnny Roughan Emeritus Professor Paul Flecknell Professor John Dark	Modulation of reperfusion injury after single lung transplantation by pentoxifylline, inositol polyanions, and SIN-1	1999
Dr Johnny Roughan Emeritus Professor Paul Flecknell	The influence of pre-anaesthetic administration of buprenorphine on the anaesthetic effects of ketamine/medetomidine and pentobarbitone in rats and the consequences of repeated anaesthesia	1999
Emeritus Professor Paul Flecknell Dr Johnny Roughan Robert Stewart	Use of oral buprenorphine ('buprenorphine jello') for postoperative analgesia in rats - A clinical trial	1999