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Browsing publications by Professor John Lunec

Newcastle AuthorsTitleYearFull text
Dr Yan Zhao
Professor John Lunec
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53degradation blockage2018
Dr Lindi Chen
Arman Esfandiari
Professor John Lunec
Professor Deborah Tweddle
Characterisation of the p53 pathway in cell lines established from TH-MYCN transgenic mouse tumours2018
Arman Esfandiari
Nan Wang
Dr Ahmed Mahdi
Erhan Aptullahoglu
Professor Penny Lovat
et al.
Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeuticstrategy in cutaneous melanoma2018
Maryam Zanjirband Zanjirband
Professor Nicola Curtin
Professor John Lunec
Combination treatment with rucaparib (Rubraca) and MDM2 inhibitors, Nutlin-3 and RG7388, has synergistic and dose reduction potential in ovarian cancer2017
Dr Aiste McCormick
Gavin Cuthbert
Dr Rachel O'Donnell
Dr Brian Wilson
Huw Thomas
et al.
Functional characterisation of a novel ovarian cancer cell line, NUOC-12017
Dr Lindi Chen
Philip Berry
Dr Jennifer Bonner
Dr Katrina Wood
Dr Gareth Veal
et al.
In vivo evaluation of the intravenous MDM2-p53 antagonist RO6839921 alone and in combination with temozolomide in TP53 wild-type orthotopic models of neuroblastoma2017
Dr Catherine Drummond
Arman Esfandiari
Dr Xiaohong Lu
Dr Claire Hutton
Dr Jennifer Jackson
et al.
TP53 mutant MDM2-amplified cell lines selected for resistance to MDM2-p53 binding antagonists retain sensitivity to ionizing radiation2016
Arman Esfandiari
Dr Sirintra Nakjang
Professor John Lunec
Chemical Inhibition of Wild-Type p53-Induced Phosphatase 1 (WIP1/PPM1D) by GSK2830371 Potentiates the Sensitivity to MDM2 Inhibitors in a p53-Dependent Manner2016
Dr Ioannis Kotsopoulos
Dr Asima Mukhopadhyay
Professor John Lunec
Professor Nicola Curtin
Ali Kucukmetin
et al.
IN VITRO SINGLE AGENT RUCAPARIB CYTOTOXICITY AND CISPLATIN CHEMO-POTENTIATION IN CERVICAL CANCER CELL LINES2016
Dr Ian Logan
Dr Urszula McClurg
Dr Dominic Jones
Daniel O'Neill
Dr Fadhel Shaheen
et al.
Nutlin-3 inhibits androgen receptor-driven c-FLIP expression, resulting in apoptosis of prostate cancer cells2016
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