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Browsing publications by Professor John Lunec

Newcastle AuthorsTitleYearFull text
Dr Chiao-En Wu
Tsin Koay
Professor Penny Lovat
Professor John Lunec
TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response2019
Dr Chiao-En Wu
Tsin Koay
Arman Esfandiari
Professor Penny Lovat
Professor John Lunec
et al.
ATM Dependent DUSP6 Modulation of p53 Involved in Synergistic Targeting of MAPK and p53 Pathways with Trametinib and MDM2 Inhibitors in Cutaneous Melanoma2019
Dr Carmela Ciardullo
Erhan Aptullahoglu
Dr Laura Woodhouse
Dr Wei-Yu Lin
Dr Jonathan Wallis
et al.
Non-genotoxic MDM2 inhibition selectively induces pro-apoptotic p53 gene signature in chronic lymphocytic leukemia cells2019
Vahinipriya Manoharan
Professor John Lunec
Nucleotide variants and protein expression of TP53 in a Sri Lankan cohort of patients with head and neck cancer2019
Dr Lindi Chen
Philip Berry
Dr Jennifer Bonner
Calum Kirk
Dr Katrina Wood
et al.
Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma2019
Dr Yan Zhao
Professor John Lunec
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53degradation blockage2018
Honorine Lebraud
Dr Richard Noble
Nicole Phillips
Dr Yan Zhao
Emeritus Professor Herbie Newell
et al.
A highly potent clickable probe for cellular imaging of MDM2 and assessing dynamic responses to MDM2-p53 inhibition2018
Dr Lindi Chen
Arman Esfandiari
Professor John Lunec
Professor Deborah Tweddle
Characterisation of the p53 pathway in cell lines established from TH-MYCN transgenic mouse tumours2018
Lucy Gentles
Liz Matheson
Dr Nicholas Bown
Alice Bradbury
Maryam Zanjirband Zanjirband
et al.
Characterization and drug sensitivity of a novel human overian clear cell carcinoma cell line genomically and phenotypically similar to the original tumor2018
Arman Esfandiari
Nan Wang
Dr Ahmed Mahdi
Erhan Aptullahoglu
Professor Penny Lovat
et al.
Targeting negative regulation of p53 by MDM2 and WIP1 as a therapeuticstrategy in cutaneous melanoma2018
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