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Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?

Lookup NU author(s): Dr Luisa Wakeling, Laura Ions, Professor Dianne Ford


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Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing. We propose the novel hypothesis that effects of DR relevant to lifespan extension include maintenance of DNA methylation patterns through Sirt1-mediated epigenetic effects, and proffer the view that dietary components, including resveratrol, may mimic these actions.

Publication metadata

Author(s): Wakeling LA, Ions LJ, Ford D

Publication type: Article

Journal: Age

Year: 2009

Volume: 31

Issue: 4

Pages: 327-341

ISSN (print): 0161-9152

ISSN (electronic): 1574-4647

Publisher: Springer Netherlands


DOI: 10.1007/s11357-009-9104-5


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