Lookup NU author(s): Dr Luisa Wakeling,
Professor Dianne Ford
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Dietary restriction (DR) increases lifespan in a range of evolutionarily distinct species. The polyphenol resveratrol may be a dietary mimetic of some effects of DR. The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing suggests it may be the common conduit through which these dietary interventions influence ageing. We propose the novel hypothesis that effects of DR relevant to lifespan extension include maintenance of DNA methylation patterns through Sirt1-mediated epigenetic effects, and proffer the view that dietary components, including resveratrol, may mimic these actions.
Author(s): Wakeling LA, Ions LJ, Ford D
Publication type: Article
ISSN (print): 0161-9152
ISSN (electronic): 1574-4647
Publisher: Springer Netherlands
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