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Nociceptin-induced modulation of human T cell function

Lookup NU author(s): Dr Rachel Harry

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Abstract

There is an accumulating evidence for the immunoregulatory role of the neuropeptide, nociceptin/orphanin FQ (N/OFQ) however its role on T cell function requires elucidation. This study has demonstrated an inhibitory role for N/OFQ on SEB-activated T cell function. N/OFQ decreases T cell proliferation, which is abrogated when the costimulatory receptors CD80 and CD86 are blocked. In addition, evidence suggests that the immunoregulatory cytokines TGF-beta, IFN-gamma and nitric oxide (NO) are involved in the N/OFQ effect. N/OFQ also, through involvement of IFN and NO, induces the expression of the immunosuppressive modulator indoleamine 2,3-dioxygenase (IDO), suggesting a central role for IDO in the N/OFQ effect on T cell proliferation. The data presented in this report indicate a multi-faceted mechanism of action used by N/OFQ to modulate T cell function. (C) 2009 Elsevier Inc. All rights reserved.

Publication metadata

Author(s): Easten KH, Harry RA, Purcell WM, McLeod JD

Publication type: Article

Publication status: Published

Journal: Peptides

Year: 2009

Volume: 30

Issue: 5

Pages: 926-934

ISSN (print): 0196-9781

ISSN (electronic): 1873-5169

Publisher: Elsevier Inc.

URL: http://dx.doi.org/10.1016/j.peptides.2009.01.021

DOI: 10.1016/j.peptides.2009.01.021

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