Lookup NU author(s): Dr Ran Yan
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3-Substituted-5-phenylmorpholinones have been demonstrated to act as N-protected C-terminus activated alpha-amino acids capable of undergoing solution phase N-terminus peptide extension following standard coupling procedures. The N-acylated morpholinones do not undergo epimerisation of the stereocentre of the C-terminus amino acid residue as oxazolone formation is sterically prevented, although C-terminus peptide coupling is still possible. This convergent approach to peptide synthesis is exemplified by the preparation of L-ala-L-ala-L-ala and L-ala-D-ala-L-ala. Copyright (c) 2008 European Peptide Society and John Wiley & Sons, Ltd.
Author(s): Harwood LM, Mountford SJ, Yan R
Publication type: Article
Publication status: Published
Journal: Journal of Peptide Science
ISSN (print): 1075-2617
ISSN (electronic): 1099-1387
Publisher: John Wiley & Sons Ltd.
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