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Development of dendritic cell-based immunotherapy for autoimmunity

Lookup NU author(s): Dr Catharien Hilkens, Professor John Isaacs

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Abstract

Dendritic cells are professional antigen-presenting cells that maintain immune tolerance to self-antigens by deleting or controlling the pathogenicity of auto-reactive T-cells. Dendritic cell-based immunotherapies show great promise for the restoration of tolerance in autoimmune disease. Dendritic cells can be modified ex vivo to induce stable tolerogenic function and be used as cellular ‘vaccines’ or they can be targeted in vivo with sophisticated antigen delivery systems. Tolerogenic dendritic cells induce antigen-specific T-cell tolerance in vivo and have therapeutic effects in animal models of autoimmunity. The current challenge is to bring tolerogenic dendritic cell therapy to the clinic.


Publication metadata

Author(s): Hilkens CM, Isaacs JD, Thomson AW

Publication type: Review

Journal: International Reviews of Immunology

Year: 2010

Volume: 29

Issue: 2

Pages: 156-183

Print publication date: 01/04/2010

ISSN (print): 0883-0185

ISSN (electronic): 1563-5244

URL: http://dx.doi.org/10.3109/08830180903281193

DOI: 10.3109/08830180903281193


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