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Counterpoint: A Diabetes Outcome Progression Trial (ADOPT): Good for Sulfonylureas?

Lookup NU author(s): Dr Ebaa Al-Ozairi, Professor Philip Home

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Abstract

A Diabetes Outcome Progression Trial (ADOPT) was conceived in the hope that the seemingly inexorable decline in islet B-cell function described with metformin, sulfonylureas, and insulin in the UK Prospective Diabetes Study (UKPDS) might be stopped or inhibited to a major degree by peroxisome proliferator–activated receptor-γ agonists, in particular rosiglitazone (1,2). It was already well recognized that the rapid early efficacy of sulfonylureas in lowering glucose was not retained to 12 months, and that metformin and thiazolidinediones had slow onset of action over months, so the design of the study necessarily had to enable decline of measures of blood glucose control to be assessed for a considerable period from 1 year onwards. However, the extent (degree and time) to which this early efficacy of the sulfonylureas in protecting against hyperglycemia would persist was not accurately known. The study also provided a good opportunity to compare durability of effect of the three classes of drugs directly in the context of some shorter-term studies since published (3).


Publication metadata

Author(s): Al-Ozairi E, Sibal S, Home P

Publication type: Article

Journal: Diabetes Care

Year: 2007

Volume: 30

Issue: 6

Pages: 1677-1680

ISSN (print): 0149-5992

ISSN (electronic): 1935-5548

Publisher: American Diabetes Association

URL: http://dx.doi.org/10.2337/dc07-0339

DOI: 10.2337/dc07-0339


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