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Isoindolinone Inhibitors of the Murine Double Minute 2 (MDM2)-p53 Protein-Protein Interaction: Structure-Activity Studies Leading to Improved Potency

Lookup NU author(s): Dr Ian Hardcastle, Alex Liu, Dr Eric Valeur, Anna Watson, Shafiq Ahmed, Dr Tim Blackburn, Dr Karim Bennaceur, Emeritus Professor Bill Clegg, Dr Catherine Drummond, Professor Jane Endicott, Professor Bernard Golding, Professor Roger Griffin, Dr Karen Haggerty, Dr Ross Harrington, Dr Claire Hutton, Stuart Kemp, Dr Xiaohong Lu, Professor Herbie Newell, Professor Martin Noble, Sara Payne, Charlotte Revill, Qing Xu, Professor John Lunec

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Author(s): Hardcastle IR, Liu J, Valeur E, Watson A, Ahmed SU, Blackburn TJ, Bennaceur K, Clegg W, Drummond C, Endicott JA, Golding BT, Griffin RJ, Gruber J, Haggerty K, Harrington RW, Hutton C, Kemp S, Lu X, McDonnell JM, Newell DR, Noble ME, Payne SL, Revill CH, Riedinger C, Xu Q, Lunec J

Publication type: Article

Journal: Journal of Medicinal Chemistry

Year: 2011

Volume: 54

Issue: 5

Pages: 1233-1243

Print publication date: 11/02/2011

ISSN (print): 0022-2623

ISSN (electronic): 1520-4804

Publisher: American Chemical Society

URL: http://dx.doi.org/10.1021/jm1011929

DOI: 10.1021/jm1011929

PubMed id: 21314128


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