Lookup NU author(s): Dr Ahmad Khundakar,
Dr Christopher Morris,
Professor Alan Thomas
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Previous imaging and morphometric studies have identified volumetric and cellular abnormalities in prefrontal areas in late-life depression. This study aimed to examine cellular morphology using stereological methodology in the supragenual region of the anterior cingulate cortex in late-life depressed patients compared with age-matched controls. Post-mortem tissue was acquired from nine patients with depression and 11 control patients and analyzed using the optical disector and nucleator methods. No changes were found in glial, non-pyramidal and pyramidal cell density, or in non-pyramidal or pyramidal cell volume within individual layers (2-5) or the supragenual anterior cortex as a whole. This study, therefore, does not provide further evidence for cellular abnormalities in late-life depression.
Author(s): Khundakar AA, Morris CM, Oakley AE, Thomas AJ
Publication type: Article
Journal: Psychiatry Research: Neuroimaging
Print publication date: 30/11/2011
ISSN (print): 0925-4927
ISSN (electronic): 1872-7506
Publisher: Elsevier Ireland Ltd
PubMed id: 21924875
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