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Self-Organisation of Self-Complementary DNA Molecules Covalently Attached to Silicon Surfaces

Lookup NU author(s): Dr Rebeca Gonzalez, Dr Samson Patole, Professor Bernard Connolly, Professor Andrew Houlton, Dr Ben Horrocks, Dr Andrew Pike

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Abstract

Self-complementary oligonucleotides were synthesized at atomically-flat Si(111) surfaces and their hybridization reaction was studied using atomic force microscopy. Annealing these surfaces in aqueous media, in the absence of any other reagents or DNA, resulted in a self-organization process in which hybridization produced well-defined features in the AFM images. By varying the surface coverage of DNA we provide evidence that the features observed are due to inter-strand rather than intra-strand hybridization reactions.


Publication metadata

Author(s): Carlsson S, Gonzalez R, O'Farrell N, Patole SN, Connolly BA, Houlton A, Horrocks BR, Pike A

Publication type: Article

Journal: Science of Advanced Materials

Year: 2011

Volume: 3

Issue: 3

Pages: 483-489

Print publication date: 01/06/2011

ISSN (print): 1947-2935

ISSN (electronic): 1947-2943

Publisher: American Scientific Publishers

URL: http://dx.doi.org/10.1166/sam.2011.1164

DOI: 10.1166/sam.2011.1164


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