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Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study

Lookup NU author(s): Dr Carmen Martin-Ruiz, Professor Carol Jagger, Dr Andrew Kingston, Dr Joanna Collerton, Professor Mike Catt, karen Davies, Dr Michael Dunn, Dr Catharien Hilkens, Professor Bernard Keavney, Professor Simon Pearce, Wendy den Elzen, David Talbot, Laura Wiley, Professor John Bond, Professor John Mathers, Professor Martin Eccles, Professor Louise Robinson, Emeritus Professor Oliver James, Emeritus Professor Thomas Kirkwood, Professor Thomas von Zglinicki

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Abstract

Sensitive and specific biomarkers of ageing are needed to evaluate interventions to extend health span. However, there is growing evidence that information provided by candidate biomarkers may change with age itself. Little is yet known about the value of candidate biomarkers in those over 85 years, currently the fastest growing population sub-group in many countries. This study assessed a large panel of candidate biomarkers in a cohort of 85 years old by studying comparative associations with health status. Using a cross-sectional sample of 852 individuals aged 85, we performed uni- and multi-variable analyses of associations between 74 candidate biomarkers and 4 health-status measures: viz. multi-morbidity, cognitive impairment, disability and proximity to death as measured by mortality within 1.5 years. We defined as most informative any measures that were significantly associated with at least two of the health-status measures in multivariable analyses in this age group. 10 out of 74 tested candidates fulfilled this criterion, while several proposed biomarkers of ageing, notably inflammation and immune risk markers and telomere length, did not. As future data accrues on health outcomes within the cohort, it will become possible also to evaluate the predictive value of these and others of the candidate biomarkers.


Publication metadata

Author(s): Martin Ruiz C, Jagger C, Kingston A, Collerton J, Catt M, Davies K, Dunn M, Hilkens C, Keavney B, Pearce S, den Elzen W, Talbot D, Wiley L, Bond J, Mathers J, Eccles M, Robinson L, James O, Kirkwood T, von Zglinicki T

Publication type: Article

Journal: Mechanisms of Ageing and Development

Year: 2011

Volume: 132

Issue: 10

Pages: 496-502

Print publication date: 16/08/2011

ISSN (print): 0047-6374

ISSN (electronic): 1872-6216

Publisher: Elsevier Ireland Ltd

URL: http://dx.doi.org/10.1016/j.mad.2011.08.001

DOI: 10.1016/j.mad.2011.08.001


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