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Termination of Protein Synthesis in Mammalian Mitochondria

Lookup NU author(s): Professor Zofia Chrzanowska-LightowlersORCiD, Alexksandra Pajak, Professor Robert Lightowlers

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Abstract

All mechanisms of protein synthesis can be considered in four stages: initiation, elongation, termination, and ribosome recycling. Remarkable progress has been made in understanding how these processes are mediated in the cytosol of many species; however, details of organellar protein synthesis remain sketchy. This is an important omission, as defects in human mitochondrial translation are known to cause disease and may contribute to the aging process itself. In this minireview, we focus on the recent advances that have been made in understanding how one of these processes, translation termination, occurs in the human mitochondrion.

Publication metadata

Author(s): Chrzanowska-Lightowlers ZMA, Pajak A, Lightowlers RN

Publication type: Review

Publication status: Published

Journal: Journal of Biological Chemistry

Year: 2011

Volume: 286

Issue: 40

Pages: 34479-34485

Print publication date: 26/08/2011

ISSN (print): 0021-9258

ISSN (electronic): 1083-351X

Publisher: AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC

URL: http://dx.doi.org/10.1074/jbc.R111.290585

DOI: 10.1074/jbc.R111.290585

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