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Controlling cell morphology on amino acid-modified cellulose

Lookup NU author(s): Dr Deepak Kalaskar

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Abstract

This study shows that it is possible to affect the morphology and spreading of fibroblast cells on amino acid-modified cellulose-based fibrous networks. Hydrophilic (Gly, Ser), aliphatic (Ala, Val, Leu, Ile) and aromatic amino acids (Phe, Tyr, Trp), coupled to the cellulose via esterification, give rise to different cell morphologies. Modified cellulosic substrates are analysed using time of flight secondary ion mass spectrometry (TOF-SIMS), demonstrating that amino acids are coupled and uniformly distributed over the surface of the samples. Remarkably, it is shown that it is the aromatic amino acids, and in particular Trp, that give rise to significantly enhanced cell spreading. This enhanced effect is shown to be linked to an increase in the adsorption of fibronectin in the presence of aromatic bound amino acids.


Publication metadata

Author(s): Kalaskar DM, Gough JE, Ulijn RV, Sampson WW, Scurr DJ, Rutten FJ, Alexander MR, Merry CLR, Eichhorn SJ

Publication type: Article

Journal: Soft Matter

Year: 2008

Volume: 4

Issue: 5

Pages: 1059-1065

ISSN (print): 1744-683X

ISSN (electronic): 1744-6848

Publisher: Royal Society of Chemistry

URL: http://dx.doi.org/10.1039/b719706n

DOI: 10.1039/b719706n


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