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Hydrogen peroxide as a signaling molecule

Lookup NU author(s): Dr Elizabeth Veal, Dr Alison Day

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Abstract

Increases in hydrogen peroxide can initiate protective responses to limit or repair oxidative damage. However, hydrogen peroxide signals also fine-tune responses to growth factors and cytokines to control cell division,differentiation, and migration. Here we discuss some of the mechanisms by which hydrogen peroxide is sensed and utilized as a signaling molecule to regulate diverse biological processes. We also discuss how the localization and levels of hydrogen peroxide, antioxidants, and the cellular metal composition together influence the nature of the response.


Publication metadata

Author(s): Veal EA, Day AM

Publication type: Editorial

Journal: Antioxidants and Redox Signaling

Year: 2011

Volume: 15

Issue: 1

Pages: 147-151

ISSN (print): 1523-0864

ISSN (electronic): 1557-7716

Publisher: Mary Ann Liebert, Inc. Publishers

URL: http://dx.doi.org/10.1089/ars.2011.3968

DOI: 10.1089/ars.2011.3968


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