Lookup NU author(s): Elaine Hong,
Dr Hannah Gautrey,
Professor David Elliott,
Dr Alison Tyson-Capper
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Scaffold attachment factor B1 (SAFB1) and a second family member, SAFB2 are multifunctional proteins implicated in a variety of cellular processes including cell growth, apoptosis and stress response. Their potential function as tumour suppressors have been put forward based on well-described roles in transcriptional repression. This review summarises the current knowledge of SAFB1 and SAFB2 in transcriptional repression with relevance to cancer.
Author(s): Hong EA, Gautrey HL, Elliott DJ, Tyson-Capper AJ
Publication type: Review
Journal: Biochemical Society Transactions
Print publication date: 01/08/2012
ISSN (print): 0300-5127
ISSN (electronic): 1470-8752