Lookup NU author(s): Dr Julian Venables
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Alternative splicing leads to multiple proteins from individual genes and the most common deviation from the norm is precise exon omission. Mutations that cause this can be found deep in introns, especially downstream of the cassette exon. This review summarises what is known about these intronic splicing enhancers and their RNA-binding proteins that cause spliceosome assembly on the upstream exon.
Author(s): Venables JP
Publication type: Article
Journal: FEBS Letters
Print publication date: 04/09/2007
ISSN (print): 0014-5793
ISSN (electronic): 1873-3468
Publisher: Elsevier BV
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