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Downstream intronic splicing enhancers

Lookup NU author(s): Dr Julian Venables

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Abstract

Alternative splicing leads to multiple proteins from individual genes and the most common deviation from the norm is precise exon omission. Mutations that cause this can be found deep in introns, especially downstream of the cassette exon. This review summarises what is known about these intronic splicing enhancers and their RNA-binding proteins that cause spliceosome assembly on the upstream exon.


Publication metadata

Author(s): Venables JP

Publication type: Article

Journal: FEBS Letters

Year: 2007

Volume: 581

Issue: 22

Pages: 4127-4131

Print publication date: 04/09/2007

ISSN (print): 0014-5793

ISSN (electronic): 1873-3468

Publisher: Elsevier BV

URL: http://dx.doi.org/10.1016/j.febslet.2007.08.012

DOI: 10.1016/j.febslet.2007.08.012


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