Lookup NU author(s): Professor Hamish McAllister-Williams
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Objective: To determine the effectiveness of agomelatine in routine clinical practice and explore factors associated with response and continuation. Method: Consecutive patients prescribed agomelatine in participating psychiatric services were included. Patient demographic and outcome data were collected at treatment initiation and then at weeks 4, 8 and 12. Outcomes were analysed with respect to clinical and demographic factors. Results: A total of 110 patients from nine NHS trusts were followed through 12 weeks of treatment. Agomelatine was largely used in difficult-to-treat or refractory patients: 83 (75%) had failed to respond to, or relapsed on, prior antidepressants. There were high rates of physical (54.5%) and psychiatric (50.0%) comorbidity. At 12 weeks of treatment, 68 (62%) continued agomelatine treatment. Overall, 69 subjects (62.7%) improved by at least one point of the Clinical Global Impression (severity) scale. Of 42 who discontinued, 23 (56%) discontinued because of lack of efficacy and 10 (24%) due to an adverse event. Of all variables examined, only a history of more than five episodes of depression significantly predicted discontinuation of treatment (OR continuation -0.36, 95% CI 0.14, 0.95). Conclusion: Agomelatine was effective and generally well tolerated in a cohort of difficult-to-treat patients in clinical practice.
Author(s): Sparshatt A, McAllister Williams RH, Baldwin DS, Haddad PM, Bazire S, Weston E, Taylor P, Taylor D
Publication type: Article
Publication status: Published
Journal: Acta Psychiatrica Scandinavica
Print publication date: 14/12/2012
ISSN (print): 0001-690X
ISSN (electronic): 1600-5473
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