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Biomimetic polyurethane - Based fibrous scaffolds

Lookup NU author(s): Dr Piergiorgio Gentile

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Abstract

The design of biomimetic scaffolds that reproduce the biochemical, mechanical and structural functions of the ECM is a fundamental requirement to develop functional substrate for tissue engineering. To this aim, materials which combine the easy processability and mechanical properties of synthetic polymers with the biochemical cues provided by natural materials, develop positive interaction with cells, enabling tissue regrowth in vivo. In this work, a polyester urethane (NS-BC2000) was synthesised using poly (ε-caprolactone) diol (PCL) as macrodiol, 1,4-diisocyanatobutane (BDI) as diisocyanate and N-Boc serinol as chain extender. After Boc cleavage (S-BC2000) to expose free amino groups, a S-BC2000/PEO (80/20 wt./wt.) solution was successfully electrospun fabricating aligned nanofibres with a fibre size of 2.8±0.6 µm.


Publication metadata

Author(s): Tonda-Turo C, Boffito M, Cassino C, Gentile P, Ciardelli G

Publication type: Article

Journal: Materials Letters

Year: 2016

Volume: 167

Pages: 9-12

Online publication date: 29/12/2015

Acceptance date: 26/12/2015

Print publication date: 15/03/2016

ISSN (print): 0167-577X

ISSN (electronic): 1873-4979

Publisher: Elsevier

URL: http://www.sciencedirect.com/science/article/pii/S0167577X15310703

DOI: 10.1016/j.matlet.2015.12.117


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