Lookup NU author(s): Emel Okan,
Dr Peter Jones
Full text for this publication is not currently held within this repository. Alternative links are provided below where available.
How cell adhesion is coordinated with extracellular proteolysis is a key question in understanding cell migration. Potentially, the small GTP-binding proteins that affect actin organisation and signal transduction may also regulate the expression of genes associated with extracellular proteolysis. We investigated the ability of Ras, Rac-1, Cdc42Hs, and RhoA to regulate transcription from the1.55-kb promoter region of the human urokinase plasminogen activator receptor (uPAR) gene. Constitutively active V12 H-Ras and Rho-A stimulated uPAR transcription while Cdc42Hs and Rac-1 did not. The use of Ras effector-loop mutants indicated that signalling via multiple Ras-effectors is necessary for the maximum activation of transcription. Copyright 2000 Academic Press.
Author(s): Okan E; Jones P; Muller SM
Publication type: Article
Journal: Biochemical & Biophysical Research Communications
ISSN (print): 0006-291X
ISSN (electronic): 1090-2104
Publisher: Academic Press
Altmetrics provided by Altmetric