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The role of extracorporeal photopheresis in the management of cutaneous T-cell lymphoma, graft-versus-host disease and organ transplant rejection: a consensus statement update from the UK Photopheresis Society

Lookup NU author(s): Dr Andrew Gennery, Julie Guest, Professor Andrew Fisher

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This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).


Abstract

© 2017 John Wiley & Sons Ltd. Extracorporeal photopheresis (ECP) has been used for over 35 years in the treatment of erythrodermic cutaneous T-cell lymphoma (CTCL) and over 20 years for chronic and acute graft-versus-host disease (GvHD) and solid organ transplant rejection. ECP for CTCL and GvHD is available at specialised centres across the UK. The lack of prospective randomised trials in ECP led to the development of UK Consensus Statements for patient selection, treatment schedules, monitoring protocols and patient assessment criteria for ECP. The recent literature has been reviewed and considered when writing this update. Most notably, the national transition from the UVAR XTS® machine to the new CELLEX machine for ECP with dual access and a shorter treatment time has led to relevant changes in these schedules. This consensus statement updates the previous statement from 2007 on the treatment of CTCL and GvHD with ECP using evidence based medicine and best medical practise and includes guidelines for both children and adults.


Publication metadata

Author(s): Alfred A, Taylor PC, Dignan F, El-Ghariani K, Griffin J, Gennery AR, Bonney D, Das-Gupta E, Lawson S, Malladi RK, Douglas KW, Maher T, Guest J, Hartlett L, Fisher AJ, Child F, Scarisbrick JJ

Publication type: Article

Publication status: Published

Journal: British Journal of Haematology

Year: 2017

Volume: 177

Issue: 2

Pages: 287-310

Print publication date: 01/04/2017

Online publication date: 21/02/2017

Acceptance date: 23/11/2016

ISSN (print): 0007-1048

ISSN (electronic): 1365-2141

Publisher: Blackwell Publishing Ltd

URL: https://doi.org/10.1111/bjh.14537

DOI: 10.1111/bjh.14537


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