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Sensing the environment: lessons from fungi.

Lookup NU author(s): Dr Julian Rutherford

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Abstract

All living organisms use numerous signal-transduction systems to sense and respond to their environments and thereby survive and proliferate in a range of biological niches. Molecular dissection of these signalling networks has increased our understanding of these communication processes and provides a platform for therapeutic intervention when these pathways malfunction in disease states, including infection. Owing to the expanding availability of sequenced genomes, a wealth of genetic and molecular tools and the conservation of signalling networks, members of the fungal kingdom serve as excellent model systems for more complex, multicellular organisms. Here, we review recent progress in our understanding of how fungal-signalling circuits operate at the molecular level to sense and respond to a plethora of environmental cues.


Publication metadata

Author(s): Bahn YS, Xue C, Idnurm A, Rutherford JC, Heitman J, Cardenas ME

Publication type: Article

Journal: Nature Reviews Microbiology

Year: 2007

Volume: 5

Issue: 1

Pages: 57-69

ISSN (print): 1740-1526

ISSN (electronic): 1740-1534

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/nrmicro1578

DOI: 10.1038/nrmicro1578


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