Lookup NU author(s): Dr Simon Doherty,
Dr Julian Knight,
Emeritus Professor Bill Clegg
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Electron-rich, bicyclic biaryl-like KITPHOS monophosphines have been prepared via Diels-Alder cycloaddition between 1-alkynylphosphine oxides and anthracene in an operationally straightforward and highly modular synthetic protocol that will allow access to an architecturally and electronically diverse family of ligands. Palladium complexes of these ligands are highly efficient catalysts for the Buchwald-Hartwig amination and Suzuki-Miyaura coupling of a wide range of aryl chlorides, which for the vast majority of substrate combinations outperform their o-(dicyclohexylphosphino)biphenyl based counterparts. Keywords: electron rich; biaryl-like; phosphine; aminations; Suzuki-Miyaura coupling; aryl chlorides.
Author(s): Doherty S, Knight JG, Smyth CH, Jorgenson GA
Publication type: Article
Journal: Advanced Synthesis & Catalysis
ISSN (print): 1615-4150
ISSN (electronic): 1615-4169
Publisher: Wiley - VCH Verlag GmbH & Co. KGaA
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