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Neuroblastoma tumour genetics: Clinical and biological aspects

Lookup NU author(s): Dr Nicholas Bown

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Abstract

Neuroblastoma tumour cells show complex combinations of acquired genetic aberrations, including ploidy changes, deletions of chromosome arms 1p and 11q, amplification of the MYCN oncogene, and - most frequently - gains of chromosome arm 17q. Despite intensive investigation, the fundamental role of these features in neuroblastoma initiation and progression remains to be understood. Nonetheless, great progress has been made in relating tumour genetic abnormalities to tumour behaviour and to clinical outcome; indeed, neuroblastoma provides a paradigm for the clinical importance of tumour genetic abnormalities. Knowledge of MYCN status is increasingly being used in treatment decisions for individual children, and the clinical value of 1p and 17q data as adjuncts or refinements in risk stratification is under active investigation. Reliable detection of these molecular cytogenetic features should be regarded as mandatory for all new cases at presentation.

Publication metadata

Author(s): Bown N

Publication type: Review

Publication status: Published

Journal: Journal of Clinical Pathology

Year: 2001

Volume: 54

Issue: 12

Pages: 897-910

Print publication date: 01/01/2001

ISSN (print): 0021-9746

ISSN (electronic): 1472-4146

URL: http://dx.doi.org/10.1136/jcp.54.12.897

DOI: 10.1136/jcp.54.12.897

PubMed id: 11729208

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