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Childhood solid tumours in relation to infections in the community in Cumbria during pregnancy and around the time of birth

Lookup NU author(s): Dr Heather Dickinson, Dr Tibor Nyari, Professor Louise Parker

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Abstract

In a retrospective cohort study of all 99976 live births in Cumbria, 1975-1992, we investigated whether higher levels of community infections during the mother's pregnancy and in early life were risk factors for solid tumours (brain/spinal and other tumours), diagnosed 1975-1993 under age 15 years. Logistic regression was used to relate risk to incidente of community infections in three prenatal and two postnatal quarters. There was an increased risk of brain/spinal tumours among children exposed around or soon after birth to higher levels of community infections, in particular measles (OR for trend=2.1, 95%Cl:1.3-3.6, P=0.008) and influenza (OR for exposure=3.3, 95%Cl:1.5-7.4, P=0.005). There was some evidente of an association between exposure to infections around and soon after birth and risk of other tumours, but this may have been a chance finding. The findings are consistent with other recent epidemiological studies suggesting brain tumours may be associated with perinatal exposure to infections. © 2002 Cancer Research UK.

Publication metadata

Author(s): Dickinson HO, Nyari TA, Parker L

Publication type: Article

Publication status: Published

Journal: British Journal of Cancer

Year: 2002

Volume: 87

Issue: 7

Pages: 746-750

ISSN (print): 0007-0920

ISSN (electronic): 1532-1827

Publisher: Nature Publishing Group

URL: http://dx.doi.org/10.1038/sj.bjc.6600530

DOI: 10.1038/sj.bjc.6600530

PubMed id: 12232758

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