Toggle Main Menu Toggle Search

Open Access padlockePrints

Environmental factors and not genotype influence the plasma level of interleukin-1 receptor antagonist in normal individuals

Lookup NU author(s): Dr Hannah Cullup, Dr Peter Middleton, Professor Anne Dickinson

Downloads

Full text for this publication is not currently held within this repository. Alternative links are provided below where available.


Abstract

Cytokine production may be regulated by both genotypic (single nucleotide or tandem repeat polymorphisms) and non-genotypic factors relating to the environment and inherent biology (i.e. gender). Interleukin (IL)-1 is one of the body's most highly proinflammatory cytokines and is implicated in the pathophysiology of numerous diseases, but also in the maintenance of homeostasis in a number of tissues. The cytokine IL-1 receptor antagonist (IL-1Ra) is the competitive inhibitor of the IL-1 agonists IL-1α and IL-1β, In vivo IL-1Ra was measured in a cohort of 200 + blood donors and the effect of the IL-1 gene polymorphisms, environmental and biological factors assessed. In this study, we observed that possession of particular alleles of 5 IL-1 gene polymorphisms (IL1A-889, IL1A VNTR, IL1B -511, IL1B +3953 and the IL1RN VNTR) did not correlate with higher plasma IL-1Ra levels. Environmental factors such as smoking and non-steroidal anti-inflammatory drug ingestion were associated with higher in vivo IL-1Ra levels (P= 0.015 and 0.022, respectively), but biological factors such as gender, age and menstruation status did not have any impact upon in vivo IL-1Ra levels. Genotypic associations of IL-1 gene family polymorphisms with disease features may reflect characteristics of stressed rather than normal control circuits for cytokine production.


Publication metadata

Author(s): Cullup H, Middleton PG, Duggan G, Conn JS, Dickinson AM

Publication type: Article

Publication status: Published

Journal: Clinical and Experimental Immunology

Year: 2004

Volume: 137

Issue: 2

Pages: 351-358

Print publication date: 01/08/2004

ISSN (print): 0009-9104

ISSN (electronic): 1365-2249

Publisher: Wiley-Blackwell

URL: http://dx.doi.org/10.1111/j.1365-2249.2004.02531.x

DOI: 10.1111/j.1365-2249.2004.02531.x

PubMed id: 15270852


Altmetrics

Altmetrics provided by Altmetric


Share